Kilmarx P H, Knapp J S, Xia M, St Louis M E, Neal S W, Sayers D, Doyle L J, Roberts M C, Whittington W L
National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
J Infect Dis. 1998 Mar;177(3):677-82. doi: 10.1086/514234.
Patients and gonococcal isolates (n = 783) from five sexually transmitted disease clinics in Ohio and western Pennsylvania were studied to investigate the spread of gonococci with decreased fluoroquinolone susceptibility. Among patients with gonorrhea, rates of infection with strains with decreased fluoroquinolone susceptibility (MIC of 0.125-0.25 microg ciprofloxacin/mL) were 20% for Cleveland, 9% for Akron, 7% for Columbus, 1% for Toledo, and 0.5% for Pittsburgh. Persons infected with strains with decreased susceptibility were more likely than those with susceptible strains to be male and older; no significant differences in sex behaviors, residence of sex partners, or recent antibiotic use were detected. Prevalence of decreased susceptibility was not correlated with reported levels of community fluoroquinolone use. The Pro/IB-3 auxotype/serovar class accounted for 80% (44/55) of isolates with decreased susceptibility. Pro/IB-3 isolates from three cities had indistinguishable pulsed-field gel electrophoresis patterns, suggesting intercity spread of a clone.
对来自俄亥俄州和宾夕法尼亚州西部五家性传播疾病诊所的患者及淋球菌分离株（n = 783）进行了研究，以调查氟喹诺酮敏感性降低的淋球菌的传播情况。在淋病患者中，氟喹诺酮敏感性降低菌株（环丙沙星MIC为0.125 - 0.25μg/mL）的感染率在克利夫兰为20%，阿克伦为9%，哥伦布为7%，托莱多为1%，匹兹堡为0.5%。感染敏感性降低菌株的人比感染敏感菌株的人更可能为男性且年龄更大；在性行为、性伴侣居住地或近期抗生素使用方面未检测到显著差异。敏感性降低的患病率与社区氟喹诺酮使用的报告水平无关。Pro/IB - 3辅助型/血清型类别占敏感性降低分离株的80%（44/55）。来自三个城市的Pro/IB - 3分离株具有难以区分的脉冲场凝胶电泳图谱，表明一个克隆在城市间传播。
