N-氯代牛磺酸对念珠菌属菌株活力及分泌天冬氨酸蛋白酶产生的影响
Impact of N-chlorotaurine on viability and production of secreted aspartyl proteinases of Candida spp.
作者信息
Nagl Markus, Gruber Andreas, Fuchs Anita, Lell Claudia P, Lemberger Eva-Maria, Borg-Von Zepelin Margarete, Würzner Reinhard
机构信息
Institute of Hygiene and Social Medicine, Leopold-Franzens-University of Innsbruck, Innsbruck, Austria.
出版信息
Antimicrob Agents Chemother. 2002 Jun;46(6):1996-9. doi: 10.1128/AAC.46.6.1996-1999.2002.
Abstract
N-Chlorotaurine, an endogenous long-lived oxidant, demonstrated fungicidal activity against Candida spp. and a postantifungal effect. Secreted aspartyl proteinases, important fungal virulence factors, proved to be a first target of impact. These results provide support for the topical application of N-chlorotaurine as an antimicrobial agent in yeast infections.
摘要
N-氯牛磺酸是一种内源性的长效氧化剂，对念珠菌属具有杀真菌活性和抗真菌后效应。分泌性天冬氨酸蛋白酶是重要的真菌毒力因子，被证明是其首个作用靶点。这些结果为N-氯牛磺酸作为抗微生物剂局部应用于酵母菌感染提供了支持。
相似文献
1
Impact of N-chlorotaurine on viability and production of secreted aspartyl proteinases of Candida spp.
Antimicrob Agents Chemother. 2002 Jun;46(6):1996-9. doi: 10.1128/AAC.46.6.1996-1999.2002.
2
Development and testing of inhibitors of Candida aspartic proteinases.
Adv Exp Med Biol. 1998;436:329-33. doi: 10.1007/978-1-4615-5373-1_45.
3
Enhanced fungicidal activity of N-chlorotaurine in nasal secretion.
J Antimicrob Chemother. 2001 Jun;47(6):871-4. doi: 10.1093/jac/47.6.871.
4
A new plate assay for detecting inhibitors of Candida aspartyl proteinase.
J Antibiot (Tokyo). 2000 Feb;53(2):201-3. doi: 10.7164/antibiotics.53.201.
5
Interaction of sertraline with Candida species selectively attenuates fungal virulence in vitro.
FEMS Immunol Med Microbiol. 2003 Jan 21;35(1):11-5. doi: 10.1111/j.1574-695X.2003.tb00643.x.
6
Anti-fungal therapy at the HAART of viral therapy.
Trends Microbiol. 2002 Apr;10(4):173-7. doi: 10.1016/s0966-842x(02)02330-2.
7
Effect of N-chlorotaurine on Aspergillus, with particular reference to destruction of secreted gliotoxin.
J Med Microbiol. 2006 Jul;55(Pt 7):913-918. doi: 10.1099/jmm.0.46405-0.
8
HIV proteinase inhibitors: do they really work against Candida in a clinical setting?
Trends Microbiol. 2002 Apr;10(4):177-8. doi: 10.1016/s0966-842x(02)02341-7.
9
The secreted aspartic proteinases as a new target in the therapy of candidiasis.
Curr Drug Targets. 2002 Oct;3(5):351-7. doi: 10.2174/1389450023347542.
10
Exposure to therapeutic concentrations of ritonavir, but not saquinavir, reduces secreted aspartyl proteinase of Candida parapsilosis.
Chemotherapy. 2005 Aug;51(5):252-5. doi: 10.1159/000087252. Epub 2005 Jul 26.
引用本文的文献
1
Sequence Variation of Candida albicans Sap2 Enhances Fungal Pathogenicity via Complement Evasion and Macrophage M2-Like Phenotype Induction.
Adv Sci (Weinh). 2023 Jul;10(20):e2206713. doi: 10.1002/advs.202206713. Epub 2023 May 21.
2
Comparative Fungicidal Activities of N-Chlorotaurine and Conventional Antiseptics against spp. Isolated from Vulvovaginal Candidiasis.
J Fungi (Basel). 2022 Jun 28;8(7):682. doi: 10.3390/jof8070682.
3
Current Opinion on the Therapeutic Capacity of Taurine-Containing Halogen Derivatives in Infectious and Inflammatory Diseases.
Adv Exp Med Biol. 2022;1370:83-98. doi: 10.1007/978-3-030-93337-1_8.
4
N-chlorotaurine is highly active against respiratory viruses including SARS-CoV-2 (COVID-19) .
Emerg Microbes Infect. 2022 Dec;11(1):1293-1307. doi: 10.1080/22221751.2022.2065932.
5
Activity of -Chlorotaurine against Long-Term Biofilms of Bacteria and Yeasts.
Antibiotics (Basel). 2021 Jul 22;10(8):891. doi: 10.3390/antibiotics10080891.
6
N-Chlorotaurine, a Promising Future Candidate for Topical Therapy of Fungal Infections.
Mycopathologia. 2018 Feb;183(1):161-170. doi: 10.1007/s11046-017-0175-z. Epub 2017 Jul 12.
7
Microbicidal activity of N-chlorotaurine in combination with hydrogen peroxide.
AMB Express. 2017 Dec;7(1):102. doi: 10.1186/s13568-017-0404-3. Epub 2017 May 23.
8
Bactericidal and Fungicidal Activity of -Chlorotaurine Is Enhanced in Cystic Fibrosis Sputum Medium.
Antimicrob Agents Chemother. 2017 Apr 24;61(5). doi: 10.1128/AAC.02527-16. Print 2017 May.
9
N-Chlorotaurine Exhibits Fungicidal Activity against Therapy-Refractory Scedosporium Species and Lomentospora prolificans.
Antimicrob Agents Chemother. 2015 Oct;59(10):6454-62. doi: 10.1128/AAC.00957-15. Epub 2015 Aug 3.
10
N-chloramines, a promising class of well-tolerated topical anti-infectives.
Antimicrob Agents Chemother. 2013 Mar;57(3):1107-14. doi: 10.1128/AAC.02132-12. Epub 2013 Jan 7.
本文引用的文献
1
Candida albicans proteinases: resolving the mystery of a gene family.
Microbiology (Reading). 2001 Aug;147(Pt 8):1997-2005. doi: 10.1099/00221287-147-8-1997.
2
Influence of pH and concentration on the postantifungal effect and on the effects of sub-MIC concentrations of 4 antifungal agents on previously treated Candida spp.
Scand J Infect Dis. 2000;32(6):669-73. doi: 10.1080/003655400459603.
3
In vitro pharmacodynamic characteristics of nystatin including time-kill and postantifungal effect.
Antimicrob Agents Chemother. 2000 Oct;44(10):2887-90. doi: 10.1128/AAC.44.10.2887-2890.2000.
4
Bactericidal activity of micromolar N-chlorotaurine: evidence for its antimicrobial function in the human defense system.
Antimicrob Agents Chemother. 2000 Sep;44(9):2507-13. doi: 10.1128/AAC.44.9.2507-2513.2000.
5
Differential activation of a Candida albicans virulence gene family during infection.
Proc Natl Acad Sci U S A. 2000 May 23;97(11):6102-7. doi: 10.1073/pnas.110031497.
6
Tolerance of N-chlorotaurine, a new antimicrobial agent, in infectious conjunctivitis - a phase II pilot study.
Ophthalmologica. 2000;214(2):111-4. doi: 10.1159/000027477.
7
Regulation of murine dendritic cell functions in vitro by taurine chloramine, a major product of the neutrophil myeloperoxidase-halide system.
Immunology. 1999 Nov;98(3):371-8. doi: 10.1046/j.1365-2567.1999.00905.x.
8
Dissimilar attenuation of Candida albicans virulence properties by human immunodeficiency virus type 1 protease inhibitors.
Immunobiology. 1999 Sep;201(1):133-44. doi: 10.1016/S0171-2985(99)80052-7.
9
The postantibiotic effect of N-chlorotaurine on Staphylococcus aureus. Application in the mouse peritonitis model.
J Antimicrob Chemother. 1999 Jun;43(6):805-9. doi: 10.1093/jac/43.6.805.
10
In vitro and in vivo anticandidal activity of human immunodeficiency virus protease inhibitors.
J Infect Dis. 1999 Aug;180(2):448-53. doi: 10.1086/314871.
Zotero 插件