N-氯代牛磺酸对念珠菌属菌株活力及分泌天冬氨酸蛋白酶产生的影响
Impact of N-chlorotaurine on viability and production of secreted aspartyl proteinases of Candida spp.
作者信息
Nagl Markus, Gruber Andreas, Fuchs Anita, Lell Claudia P, Lemberger Eva-Maria, Borg-Von Zepelin Margarete, Würzner Reinhard
机构信息
Institute of Hygiene and Social Medicine, Leopold-Franzens-University of Innsbruck, Innsbruck, Austria.
出版信息
Antimicrob Agents Chemother. 2002 Jun;46(6):1996-9. doi: 10.1128/AAC.46.6.1996-1999.2002.
Abstract
N-Chlorotaurine, an endogenous long-lived oxidant, demonstrated fungicidal activity against Candida spp. and a postantifungal effect. Secreted aspartyl proteinases, important fungal virulence factors, proved to be a first target of impact. These results provide support for the topical application of N-chlorotaurine as an antimicrobial agent in yeast infections.
摘要
N-氯牛磺酸是一种内源性的长效氧化剂，对念珠菌属具有杀真菌活性和抗真菌后效应。分泌性天冬氨酸蛋白酶是重要的真菌毒力因子，被证明是其首个作用靶点。这些结果为N-氯牛磺酸作为抗微生物剂局部应用于酵母菌感染提供了支持。
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