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本文引用的文献

1
Identification of a plasmid encoding SHV-12, TEM-1, and a variant of IMP-2 metallo-beta-lactamase, IMP-8, from a clinical isolate of Klebsiella pneumoniae.从肺炎克雷伯菌临床分离株中鉴定出一种编码SHV-12、TEM-1和IMP-2金属β-内酰胺酶变体IMP-8的质粒。
Antimicrob Agents Chemother. 2001 Aug;45(8):2368-71. doi: 10.1128/AAC.45.8.2368-2371.2001.
2
Plasmid-encoded metallo-beta-lactamase (IMP-6) conferring resistance to carbapenems, especially meropenem.质粒编码的金属β-内酰胺酶（IMP-6）赋予对碳青霉烯类抗生素，尤其是美罗培南的耐药性。
Antimicrob Agents Chemother. 2001 May;45(5):1343-8. doi: 10.1128/AAC.45.5.1343-1348.2001.
3
IMP-4, a novel metallo-beta-lactamase from nosocomial Acinetobacter spp. collected in Hong Kong between 1994 and 1998.IMP-4，一种于1994年至1998年期间在香港收集的医院不动杆菌属中的新型金属β-内酰胺酶。
Antimicrob Agents Chemother. 2001 Mar;45(3):710-4. doi: 10.1128/AAC.45.3.710-714.2001.
4
Occurrence of a new metallo-beta-lactamase IMP-4 carried on a conjugative plasmid in Citrobacter youngae from the People's Republic of China.在中国一株杨氏柠檬酸杆菌中，一种携带在接合性质粒上的新型金属β-内酰胺酶IMP-4的出现。
FEMS Microbiol Lett. 2001 Jan 1;194(1):53-7. doi: 10.1111/j.1574-6968.2001.tb09445.x.
5
Amino acid substitutions in a variant of IMP-1 metallo-beta-lactamase.IMP-1金属β-内酰胺酶变体中的氨基酸替换
Antimicrob Agents Chemother. 2000 Aug;44(8):2023-7. doi: 10.1128/AAC.44.8.2023-2027.2000.
6
Characterization of the metallo-beta-lactamase determinant of Acinetobacter baumannii AC-54/97 reveals the existence of bla(IMP) allelic variants carried by gene cassettes of different phylogeny.鲍曼不动杆菌AC-54/97金属β-内酰胺酶决定簇的特征分析揭示了不同系统发育的基因盒所携带的bla(IMP)等位基因变体的存在。
Antimicrob Agents Chemother. 2000 May;44(5):1229-35. doi: 10.1128/AAC.44.5.1229-1235.2000.
7
Crystal structure of the IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: binding determinants of a potent, broad-spectrum inhibitor.铜绿假单胞菌IMP-1金属β-内酰胺酶的晶体结构及其与巯基羧酸盐抑制剂的复合物：一种强效广谱抑制剂的结合决定因素
Biochemistry. 2000 Apr 18;39(15):4288-98. doi: 10.1021/bi992569m.
8
Detection of carbapenemase-producing Acinetobacter baumannii in a hospital.医院中产碳青霉烯酶鲍曼不动杆菌的检测
J Clin Microbiol. 2000 Feb;38(2):526-9. doi: 10.1128/JCM.38.2.526-529.2000.
9
Identification and characterization of class 1 integrons in bacteria from an aquatic environment.水生环境细菌中1类整合子的鉴定与特征分析
J Antimicrob Chemother. 1999 Jul;44(1):11-8. doi: 10.1093/jac/44.1.11.
10
Biochemical characterization of the Pseudomonas aeruginosa 101/1477 metallo-beta-lactamase IMP-1 produced by Escherichia coli.由大肠杆菌产生的铜绿假单胞菌101/1477金属β-内酰胺酶IMP-1的生化特性
Antimicrob Agents Chemother. 1999 Apr;43(4):902-6. doi: 10.1128/AAC.43.4.902.

从两株不相关的铜绿假单胞菌菌株和一株木糖氧化产碱杆菌菌株中检测到一种变异金属β-内酰胺酶IMP-10。

Detection of a variant metallo-beta-lactamase, IMP-10, from two unrelated strains of Pseudomonas aeruginosa and an alcaligenes xylosoxidans strain.

作者信息

Iyobe Shizuko, Kusadokoro Haruko, Takahashi Ayako, Yomoda Sachie, Okubo Toyoji, Nakamura Akio, O'Hara Koji

机构信息

Laboratory of Drug Resistance in Bacteria, Gunma University School of Medicine, Maebashi, Japan.

出版信息

Antimicrob Agents Chemother. 2002 Jun;46(6):2014-6. doi: 10.1128/AAC.46.6.2014-2016.2002.

DOI:10.1128/AAC.46.6.2014-2016.2002
PMID:12019129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC127220/
Abstract

The gene bla(IMP-10) of a variant metallo-beta-lactamase, IMP-10, had a single base replacement of G by T at nucleotide 145, which led to an amino acid alteration of Val49 to Phe compared to the IMP-1 enzyme, indicating that IMP-10 was a point mutation derivative of IMP-1. Highly purified enzymes revealed that IMP-10 was different from IMP-1 in its extremely low hydrolyzing activities for penicillins, such as benzylpenicillin, ampicillin, and piperacillin.

摘要

一种变异金属β-内酰胺酶IMP-10的基因bla(IMP-10)在核苷酸145处发生了单个碱基G被T替换的情况，与IMP-1酶相比，这导致第49位氨基酸由缬氨酸变为苯丙氨酸，表明IMP-10是IMP-1的点突变衍生物。高纯度酶显示，IMP-10与IMP-1不同，它对青霉素（如苄青霉素、氨苄青霉素和哌拉西林）的水解活性极低。