在远交半同胞家系中同时挖掘连锁和连锁不平衡以精细定位数量性状基因座：重新审视对奶牛14号染色体产奶量有主要影响的一个数量性状基因座的位置
Simultaneous mining of linkage and linkage disequilibrium to fine map quantitative trait loci in outbred half-sib pedigrees: revisiting the location of a quantitative trait locus with major effect on milk production on bovine chromosome 14.
作者信息
Farnir Frédéric, Grisart Bernard, Coppieters Wouter, Riquet Juliette, Berzi Paulette, Cambisano Nadine, Karim Latifa, Mni Myriam, Moisio Sirja, Simon Patricia, Wagenaar Danny, Vilkki Johanna, Georges Michel
机构信息
Department of Genetics, Faculty of Veterinary Medicine, University of Liège (B43), 4000-Liège, Belgium.
出版信息
Genetics. 2002 May;161(1):275-87. doi: 10.1093/genetics/161.1.275.
Abstract
A maximum-likelihood QTL mapping method that simultaneously exploits linkage and linkage disequilibrium and that is applicable in outbred half-sib pedigrees is described. The method is applied to fine map a QTL with major effect on milk fat content in a 3-cM marker interval on proximal BTA14. This proximal location is confirmed by applying a haplotype-based association method referred to as recombinant ancestral haplotype analysis. The origin of the discrepancy between the QTL position derived in this work and that of a previous analysis is examined and shown to be due to the existence of distinct marker haplotypes associated with QTL alleles having large substitution effects.
摘要
本文描述了一种最大似然QTL定位方法，该方法同时利用连锁和连锁不平衡，适用于远交半同胞家系。该方法用于精细定位一个对乳脂率有主要影响的QTL，该QTL位于近端BTA14上一个3-cM的标记区间内。通过应用一种基于单倍型的关联方法，即重组祖先单倍型分析，证实了该近端位置。本文还研究了本研究中得出的QTL位置与先前分析结果之间差异的来源，结果表明，这是由于存在与具有较大替代效应的QTL等位基因相关的不同标记单倍型。
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