Lin Yingsong, Tamakoshi Akiko, Kawamura Takashi, Inaba Yutaka, Kikuchi Shogo, Motohashi Yutaka, Kurosawa Michiko
Department of Public Health, Aichi Medical University School of Medicine, Aichi Prefecture, Japan.
Cancer Causes Control. 2002 Apr;13(3):249-54. doi: 10.1023/a:1015052710213.
To examine the association of cigarette smoking with the risk of death from pancreatic cancer in a prospective cohort study.
A total of 110,792 inhabitants, aged 40-79 years (46,465 men and 64,327 women), were enrolled from 1988 to 1990 and followed up for mortality to the end of 1997. At baseline a self-administered questionnaire was used to obtain information on cigarette smoking and other lifestyle factors.
During the follow-up period (mean +/- SD: 8.1 +/- 1.8 years), 225 deaths due to pancreatic cancer were identified. After adjustment for age, body mass index, history of diabetes mellitus, and gallbladder diseases, the relative risks (RRs) for current smokers were 1.6 (95% CI 0.95-2.6) in males, and 1.7 (95% CI: 0.84-3.3) in females. Men who smoked more than 40 cigarettes per day had a substantially higher risk of pancreatic cancer, with a RR of 3.3 (95% CI: 1.4-8.1). A significantly decreasing trend in risk with increasing years after smoking cessation was observed (trend p = 0.04) among male ex-smokers. The RRs were 0.85 (95% CI 0.36-2.0) and 0.85 (0.36-2.0) for those who had quit smoking for 10-19 and > or =20 years, respectively.
Our cohort study confirmed that cigarette smoking was associated with an increased risk of death from pancreatic cancer.
在一项前瞻性队列研究中，探讨吸烟与胰腺癌死亡风险之间的关联。
1988年至1990年共纳入110792名年龄在40 - 79岁的居民（男性46465名，女性64327名），并随访至1997年底的死亡率情况。在基线时，采用自填式问卷获取吸烟及其他生活方式因素的信息。
在随访期间（平均±标准差：8.1±1.8年），共确认225例因胰腺癌死亡。在对年龄、体重指数、糖尿病史和胆囊疾病进行调整后，当前吸烟者的相对风险（RRs）在男性中为1.6（95%可信区间0.95 - 2.6），在女性中为1.7（95%可信区间：0.84 - 3.3）。每天吸烟超过40支的男性患胰腺癌的风险显著更高，RR为3.3（95%可信区间：1.4 - 8.1）。在男性戒烟者中，观察到随着戒烟年限增加风险显著降低的趋势（趋势p = 0.04）。戒烟10 - 19年和≥20年者的RR分别为0.85（95%可信区间0.36 - 2.0）和0.85（0.36 - 2.0）。
我们的队列研究证实，吸烟与胰腺癌死亡风险增加有关。
