通过被动转移一种中和性人类抗体在动物模型中对埃博拉病毒感染进行暴露前和暴露后预防。
Pre- and postexposure prophylaxis of Ebola virus infection in an animal model by passive transfer of a neutralizing human antibody.
作者信息
Parren Paul W H I, Geisbert Tom W, Maruyama Toshiaki, Jahrling Peter B, Burton Dennis R
机构信息
Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA.
出版信息
J Virol. 2002 Jun;76(12):6408-12. doi: 10.1128/jvi.76.12.6408-6412.2002.
Abstract
A neutralizing human monoclonal antibody, KZ52, protects guinea pigs from lethal Ebola Zaire virus challenge. Administration before or up to 1 h after challenge resulted in dose-dependent protection by the antibody. Interestingly, some antibody-treated animals survived despite developing high-level viremia, suggesting that the mechanism of protection by KZ52 may extend beyond reduction of viremia by virus neutralization. KZ52 is a promising candidate for immunoprophylaxis of Ebola virus infection.
摘要
一种中和性人源单克隆抗体KZ52可保护豚鼠免受致死性埃博拉扎伊尔病毒攻击。在攻击前或攻击后1小时内给药可产生该抗体的剂量依赖性保护作用。有趣的是，一些接受抗体治疗的动物尽管出现了高水平病毒血症仍存活下来，这表明KZ52的保护机制可能超出了通过病毒中和作用降低病毒血症的范围。KZ52是埃博拉病毒感染免疫预防的一个有前景的候选药物。
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