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J Virol. 2002 Jun;76(12):6408-12. doi: 10.1128/jvi.76.12.6408-6412.2002.
2
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本文引用的文献

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Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro.抗体在体外血清水平完全中和的情况下，可保护猕猴免受致病性R5猿猴/人类免疫缺陷病毒的阴道攻击。
J Virol. 2001 Sep;75(17):8340-7. doi: 10.1128/jvi.75.17.8340-8347.2001.
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The antiviral activity of antibodies in vitro and in vivo.抗体在体外和体内的抗病毒活性。
Adv Immunol. 2001;77:195-262. doi: 10.1016/s0065-2776(01)77018-6.
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Development of a preventive vaccine for Ebola virus infection in primates.用于灵长类动物埃博拉病毒感染的预防性疫苗的研发。
Nature. 2000 Nov 30;408(6812):605-9. doi: 10.1038/35046108.
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Fighting the Ebola virus.对抗埃博拉病毒。
Nature. 2000 Nov 30;408(6812):527-8. doi: 10.1038/35046176.
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Epitopes involved in antibody-mediated protection from Ebola virus.参与抗体介导的埃博拉病毒防护的表位。
Science. 2000 Mar 3;287(5458):1664-6. doi: 10.1126/science.287.5458.1664.
6
Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies.通过被动输注中和抗体保护猕猴免受致病性HIV-1/SIV嵌合病毒的阴道传播。
Nat Med. 2000 Feb;6(2):207-10. doi: 10.1038/72318.
7
Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection.IgG1亚型的人源中和单克隆抗体可预防黏膜猿猴-人类免疫缺陷病毒感染。
Nat Med. 2000 Feb;6(2):200-6. doi: 10.1038/72309.
8
Vaccines and the induction of functional antibodies: time to look beyond the molecules of natural infection?疫苗与功能性抗体的诱导：是时候超越自然感染的分子层面去探寻了吗？
Nat Med. 2000 Feb;6(2):123-5. doi: 10.1038/72200.
9
Ebola virus can be effectively neutralized by antibody produced in natural human infection.埃博拉病毒可被人类自然感染产生的抗体有效中和。
J Virol. 1999 Jul;73(7):6024-30. doi: 10.1128/JVI.73.7.6024-6030.1999.
10
Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies.通过中和抗体的被动转移保护猕猴免受致病性猿猴/人类免疫缺陷病毒89.6PD的侵害。
J Virol. 1999 May;73(5):4009-18. doi: 10.1128/JVI.73.5.4009-4018.1999.

通过被动转移一种中和性人类抗体在动物模型中对埃博拉病毒感染进行暴露前和暴露后预防。

Pre- and postexposure prophylaxis of Ebola virus infection in an animal model by passive transfer of a neutralizing human antibody.

作者信息

Parren Paul W H I, Geisbert Tom W, Maruyama Toshiaki, Jahrling Peter B, Burton Dennis R

机构信息

Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA.

出版信息

J Virol. 2002 Jun;76(12):6408-12. doi: 10.1128/jvi.76.12.6408-6412.2002.

DOI:10.1128/jvi.76.12.6408-6412.2002
PMID:12021376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC136210/
Abstract

A neutralizing human monoclonal antibody, KZ52, protects guinea pigs from lethal Ebola Zaire virus challenge. Administration before or up to 1 h after challenge resulted in dose-dependent protection by the antibody. Interestingly, some antibody-treated animals survived despite developing high-level viremia, suggesting that the mechanism of protection by KZ52 may extend beyond reduction of viremia by virus neutralization. KZ52 is a promising candidate for immunoprophylaxis of Ebola virus infection.

摘要

一种中和性人源单克隆抗体KZ52可保护豚鼠免受致死性埃博拉扎伊尔病毒攻击。在攻击前或攻击后1小时内给药可产生该抗体的剂量依赖性保护作用。有趣的是，一些接受抗体治疗的动物尽管出现了高水平病毒血症仍存活下来，这表明KZ52的保护机制可能超出了通过病毒中和作用降低病毒血症的范围。KZ52是埃博拉病毒感染免疫预防的一个有前景的候选药物。