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Pre- and postexposure prophylaxis of Ebola virus infection in an animal model by passive transfer of a neutralizing human antibody.通过被动转移一种中和性人类抗体在动物模型中对埃博拉病毒感染进行暴露前和暴露后预防。
J Virol. 2002 Jun;76(12):6408-12. doi: 10.1128/jvi.76.12.6408-6412.2002.
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Protective efficacy of neutralizing antibodies against Ebola virus infection.中和抗体对埃博拉病毒感染的保护效力。
Vaccine. 2007 Jan 22;25(6):993-9. doi: 10.1016/j.vaccine.2006.09.076. Epub 2006 Oct 10.
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Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys.中和抗体未能影响埃博拉病毒在猴子身上的感染进程。
PLoS Pathog. 2007 Jan;3(1):e9. doi: 10.1371/journal.ppat.0030009.
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Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection.开发一种可发挥多种功能的人源抗体鸡尾酒，以提供针对所有埃博拉病毒的保护。
Cell Host Microbe. 2019 Jan 9;25(1):39-48.e5. doi: 10.1016/j.chom.2018.12.004.
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Pan-ebolavirus and Pan-filovirus Mouse Monoclonal Antibodies: Protection against Ebola and Sudan Viruses.泛埃博拉病毒和泛丝状病毒小鼠单克隆抗体：对埃博拉病毒和苏丹病毒的保护作用
J Virol. 2015 Oct 14;90(1):266-78. doi: 10.1128/JVI.02171-15. Print 2016 Jan 1.
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Do therapeutic antibodies hold the key to an effective treatment for Ebola hemorrhagic fever?治疗性抗体是埃博拉出血热有效治疗方法的关键所在吗？
Immunotherapy. 2013 May;5(5):441-3. doi: 10.2217/imt.13.29.
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Preparation and use of hyperimmune serum for prophylaxis and therapy of Ebola virus infections.用于埃博拉病毒感染预防和治疗的高效价免疫血清的制备及应用
J Infect Dis. 1999 Feb;179 Suppl 1:S218-23. doi: 10.1086/514294.
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A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates.两株抗体泛埃博拉病毒鸡尾酒疗法在雪貂和非人灵长类动物中提供广泛的治疗保护。
Cell Host Microbe. 2019 Jan 9;25(1):49-58.e5. doi: 10.1016/j.chom.2018.12.005.
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Neutralizing the Threat: Pan-Ebolavirus Antibodies Close the Loop.中和威胁：泛埃博拉病毒抗体形成闭环。
Trends Mol Med. 2017 Aug;23(8):669-671. doi: 10.1016/j.molmed.2017.06.008. Epub 2017 Jul 8.
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Delayed treatment of cynomolgus macaques with a FVM04/CA45 monoclonal antibody cocktail provides complete protection against lethal Sudan virus infection.延迟使用 FVM04/CA45 单克隆抗体鸡尾酒治疗食蟹猴可提供针对致死性苏丹病毒感染的完全保护。
J Virol. 2024 Aug 20;98(8):e0124223. doi: 10.1128/jvi.01242-23. Epub 2024 Jul 16.
引用本文的文献
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Single-cycle, pseudotyped reporter influenza virus to facilitate evaluation of treatment strategies for avian influenza, Ebola and other highly infectious diseases .单周期、假型化报告流感病毒，以促进对禽流感、埃博拉和其他高传染性疾病治疗策略的评估。
Front Immunol. 2025 Jul 10;16:1608074. doi: 10.3389/fimmu.2025.1608074. eCollection 2025.
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Nanoscale Mechanical and Morphological Characterization of Ebolavirus-like Particles: Implications for Therapeutic Development.埃博拉病毒样颗粒的纳米级力学和形态学表征：对治疗开发的启示。
Int J Mol Sci. 2025 May 28;26(11):5185. doi: 10.3390/ijms26115185.
3
Treatment of Ebola Virus Disease: From Serotherapy to the Use of Monoclonal Antibodies.埃博拉病毒病的治疗：从血清疗法到单克隆抗体的应用。
Antibodies (Basel). 2025 Mar 5;14(1):22. doi: 10.3390/antib14010022.
4
Antiviral neutralizing antibodies: from in vitro to in vivo activity.抗病毒中和抗体：从体外到体内活性。
Nat Rev Immunol. 2023 Nov;23(11):720-734. doi: 10.1038/s41577-023-00858-w. Epub 2023 Apr 17.
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A Historical Review of Military Medical Strategies for Fighting Infectious Diseases: From Battlefields to Global Health.抗击传染病的军事医学策略历史回顾：从战场到全球健康
Biomedicines. 2022 Aug 22;10(8):2050. doi: 10.3390/biomedicines10082050.
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Combination therapy with remdesivir and monoclonal antibodies protects nonhuman primates against advanced Sudan virus disease.联合使用瑞德西韦和单克隆抗体可保护非人灵长类动物免受晚期苏丹病毒病的侵害。
JCI Insight. 2022 May 23;7(10):e159090. doi: 10.1172/jci.insight.159090.
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Therapeutic Strategies against Ebola Virus Infection.抗埃博拉病毒感染的治疗策略。
Viruses. 2022 Mar 11;14(3):579. doi: 10.3390/v14030579.
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Tracking ebolavirus genomic drift with a resequencing microarray.利用重测序微阵列追踪埃博拉病毒基因组漂移
PLoS One. 2022 Feb 10;17(2):e0263732. doi: 10.1371/journal.pone.0263732. eCollection 2022.
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Modulating Neurological Complications of Emerging Infectious Diseases: Mechanistic Approaches to Candidate Phytochemicals.调节新发传染病的神经并发症：候选植物化学物质的作用机制研究方法
Front Pharmacol. 2021 Oct 26;12:742146. doi: 10.3389/fphar.2021.742146. eCollection 2021.
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Filovirus Neutralising Antibodies: Mechanisms of Action and Therapeutic Application.丝状病毒中和抗体：作用机制与治疗应用
Pathogens. 2021 Sep 16;10(9):1201. doi: 10.3390/pathogens10091201.
本文引用的文献
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Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro.抗体在体外血清水平完全中和的情况下，可保护猕猴免受致病性R5猿猴/人类免疫缺陷病毒的阴道攻击。
J Virol. 2001 Sep;75(17):8340-7. doi: 10.1128/jvi.75.17.8340-8347.2001.
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The antiviral activity of antibodies in vitro and in vivo.抗体在体外和体内的抗病毒活性。
Adv Immunol. 2001;77:195-262. doi: 10.1016/s0065-2776(01)77018-6.
3
Development of a preventive vaccine for Ebola virus infection in primates.用于灵长类动物埃博拉病毒感染的预防性疫苗的研发。
Nature. 2000 Nov 30;408(6812):605-9. doi: 10.1038/35046108.
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Fighting the Ebola virus.对抗埃博拉病毒。
Nature. 2000 Nov 30;408(6812):527-8. doi: 10.1038/35046176.
5
Epitopes involved in antibody-mediated protection from Ebola virus.参与抗体介导的埃博拉病毒防护的表位。
Science. 2000 Mar 3;287(5458):1664-6. doi: 10.1126/science.287.5458.1664.
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Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies.通过被动输注中和抗体保护猕猴免受致病性HIV-1/SIV嵌合病毒的阴道传播。
Nat Med. 2000 Feb;6(2):207-10. doi: 10.1038/72318.
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Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection.IgG1亚型的人源中和单克隆抗体可预防黏膜猿猴-人类免疫缺陷病毒感染。
Nat Med. 2000 Feb;6(2):200-6. doi: 10.1038/72309.
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Vaccines and the induction of functional antibodies: time to look beyond the molecules of natural infection?疫苗与功能性抗体的诱导：是时候超越自然感染的分子层面去探寻了吗？
Nat Med. 2000 Feb;6(2):123-5. doi: 10.1038/72200.
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Ebola virus can be effectively neutralized by antibody produced in natural human infection.埃博拉病毒可被人类自然感染产生的抗体有效中和。
J Virol. 1999 Jul;73(7):6024-30. doi: 10.1128/JVI.73.7.6024-6030.1999.
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Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies.通过中和抗体的被动转移保护猕猴免受致病性猿猴/人类免疫缺陷病毒89.6PD的侵害。
J Virol. 1999 May;73(5):4009-18. doi: 10.1128/JVI.73.5.4009-4018.1999.
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