一种新型调控元件决定非洲爪蟾卵母细胞成熟过程中Mos mRNA翻译的时间。
A novel regulatory element determines the timing of Mos mRNA translation during Xenopus oocyte maturation.
作者信息
Charlesworth Amanda, Ridge John A, King Leslie A, MacNicol Melanie C, MacNicol Angus M
机构信息
Department of Anatomy and Neurobiology, University of Arkansas for Medical Sciences, 4301 West Markham Street Slot 814, Little Rock, AR 72205, USA.
出版信息
EMBO J. 2002 Jun 3;21(11):2798-806. doi: 10.1093/emboj/21.11.2798.
Abstract
Progression through vertebrate oocyte maturation requires that pre-existing, maternally derived mRNAs be translated in a strict temporal order. The mechanism that controls the timing of oocyte mRNA translation is unknown. In this study we show that the early translational induction of the mRNA encoding the Mos proto-oncogene is mediated through a novel regulatory element within the 3' untranslated region of the Mos mRNA. This novel element is responsive to the MAP kinase signaling pathway and is distinct from the late acting, cdc2-responsive, cytoplasmic polyadenylation element. Our findings suggest that the timing of maternal mRNA translation is controlled through signal transduction pathways targeting distinct 3' UTR mRNA elements.
摘要
脊椎动物卵母细胞成熟过程的进展要求预先存在的母源mRNA按照严格的时间顺序进行翻译。控制卵母细胞mRNA翻译时间的机制尚不清楚。在本研究中，我们表明，编码Mos原癌基因的mRNA的早期翻译诱导是通过Mos mRNA 3'非翻译区内的一个新调控元件介导的。这个新元件对MAP激酶信号通路有反应，并且不同于起后期作用的、对cdc2有反应的细胞质聚腺苷酸化元件。我们的发现表明，母源mRNA翻译的时间是通过靶向不同3'UTR mRNA元件的信号转导途径来控制的。
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本文引用的文献
1
UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs. Update 2002.
Nucleic Acids Res. 2002 Jan 1;30(1):335-40. doi: 10.1093/nar/30.1.335.
2
Cyclin B/cdc2 induces c-Mos stability by direct phosphorylation in Xenopus oocytes.
Mol Biol Cell. 2001 Sep;12(9):2660-71. doi: 10.1091/mbc.12.9.2660.
3
Identification and characterization of the gene encoding human cytoplasmic polyadenylation element binding protein.
Gene. 2001 Jan 24;263(1-2):113-20. doi: 10.1016/s0378-1119(00)00588-6.
4
The temporal control of Wee1 mRNA translation during Xenopus oocyte maturation is regulated by cytoplasmic polyadenylation elements within the 3'-untranslated region.
Dev Biol. 2000 Nov 15;227(2):706-19. doi: 10.1006/dbio.2000.9922.
5
Spacing constraints on reinitiation of paramyxovirus transcription: the gene end U tract acts as a spacer to separate gene end from gene start sites.
Virology. 2000 Sep 1;274(2):438-49. doi: 10.1006/viro.2000.0494.
6
The control of cyclin B1 mRNA translation during mouse oocyte maturation.
Dev Biol. 2000 May 1;221(1):1-9. doi: 10.1006/dbio.2000.9669.
7
Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA.
Nature. 2000 Mar 16;404(6775):302-7. doi: 10.1038/35005126.
8
Hsp90 is required for c-Mos activation and biphasic MAP kinase activation in Xenopus oocytes.
EMBO J. 2000 Apr 3;19(7):1516-24. doi: 10.1093/emboj/19.7.1516.
9
Translational control of cyclin B1 mRNA during meiotic maturation: coordinated repression and cytoplasmic polyadenylation.
Dev Biol. 2000 Apr 1;220(1):97-109. doi: 10.1006/dbio.2000.9613.
10
Absence of Wee1 ensures the meiotic cell cycle in Xenopus oocytes.
Genes Dev. 2000 Feb 1;14(3):328-38.
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