感染性心内膜炎患者的冷球蛋白血症
Cryoglobulinaemia in patients with infectious endocarditis.
作者信息
Hurwitz D, Quismorio F P, Friou G J
出版信息
Clin Exp Immunol. 1975 Jan;19(1):131-41.
Abstract
Serum cryoglobulins were found in nineteen out of twenty patients with infectious endocarditis. The cryoglobulins were of the 'mixed type' consisting of IgG, IgM and IgA. C3 and fibrinogen were present in some specimens. The concentration of the cryoglobulins tended to fall with therapy and clinical improvement of the patients. Serum antibodies to the offending bacterial organism were not preferentially concentrated in the cryoglobulins. In contrast, IgM rheumatoid factor was present in the cryoglobulins, though undetectable in the corresponding serum. These findings are consistent with the view that cryoglobulins represent circulating immune complexes which may be important in the pathogenesis of immunological sequelae sometimes found in patients with infectious endocarditis.
摘要
在20例感染性心内膜炎患者中，有19例检测到血清冷球蛋白。这些冷球蛋白属于“混合型”，由IgG、IgM和IgA组成。部分标本中存在C3和纤维蛋白原。随着治疗的进行以及患者临床症状的改善，冷球蛋白的浓度趋于下降。针对致病细菌的血清抗体并非优先浓缩在冷球蛋白中。相比之下，冷球蛋白中存在IgM类风湿因子，而在相应血清中未检测到。这些发现与以下观点一致，即冷球蛋白代表循环免疫复合物，在感染性心内膜炎患者有时出现的免疫后遗症发病机制中可能起重要作用。
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本文引用的文献
1
Systemic lupus erythematosus. Cryoprecipitation of sera.系统性红斑狼疮。血清冷沉淀反应
J Clin Invest. 1963 Jun;42(6):823-9. doi: 10.1172/JCI104774.
2
Rheumatoid factor, complement, and conglutinin aberrations in patients with subacute bacterial endocarditis.亚急性细菌性心内膜炎患者的类风湿因子、补体及胶固素异常
J Clin Invest. 1962 Mar;41(3):666-75. doi: 10.1172/JCI104523.
3
Cold precipitable serum globulins (cold fractions, cryoglovulins) in subacute bacterial endocarditis.亚急性细菌性心内膜炎中的冷沉淀血清球蛋白（冷成分，冷球蛋白）
J Lab Clin Med. 1952 Oct;40(4):489-97.
4
IgA-IgG cryoglobulinaemia with vasculitis.伴有血管炎的IgA-IgG冷球蛋白血症
Clin Exp Immunol. 1971 Aug;9(2):183-91.
5
Cryoglobulins. II. The biological and chemical properties of cryoproteins in acute post-streptococcal glomerulonephritis.冷球蛋白。二、急性链球菌感染后肾小球肾炎中冷蛋白的生物学和化学特性。
Int Arch Allergy Appl Immunol. 1971;41(5):700-15. doi: 10.1159/000230562.
6
On the nature of cryoglobulins.论冷球蛋白的性质。
J Immunol. 1968 Mar;100(3):594-603.
7
Cryoglobulinemia--a clinical and laboratory study. II. Cryoglobulins with rheumatoid factor activity.冷球蛋白血症——一项临床与实验室研究。II. 具有类风湿因子活性的冷球蛋白
Am J Med. 1966 Jun;40(6):837-56. doi: 10.1016/0002-9343(66)90200-2.
8
9
Kidney in subacute endocarditis. Pathological and immunofluorescence findings.亚急性心内膜炎中的肾脏。病理及免疫荧光检查结果。
Arch Pathol. 1972 Sep;94(3):205-13.
10
Antiviral antibodies in rheumatoid synovial fluid and cryoprecipitates.类风湿性滑液和冷沉淀物中的抗病毒抗体。
Clin Exp Immunol. 1974 Sep;18(1):27-37.
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