Hurwitz D, Quismorio F P, Friou G J
Clin Exp Immunol. 1975 Jan;19(1):131-41.
Serum cryoglobulins were found in nineteen out of twenty patients with infectious endocarditis. The cryoglobulins were of the 'mixed type' consisting of IgG, IgM and IgA. C3 and fibrinogen were present in some specimens. The concentration of the cryoglobulins tended to fall with therapy and clinical improvement of the patients. Serum antibodies to the offending bacterial organism were not preferentially concentrated in the cryoglobulins. In contrast, IgM rheumatoid factor was present in the cryoglobulins, though undetectable in the corresponding serum. These findings are consistent with the view that cryoglobulins represent circulating immune complexes which may be important in the pathogenesis of immunological sequelae sometimes found in patients with infectious endocarditis.
在20例感染性心内膜炎患者中，有19例检测到血清冷球蛋白。这些冷球蛋白属于“混合型”，由IgG、IgM和IgA组成。部分标本中存在C3和纤维蛋白原。随着治疗的进行以及患者临床症状的改善，冷球蛋白的浓度趋于下降。针对致病细菌的血清抗体并非优先浓缩在冷球蛋白中。相比之下，冷球蛋白中存在IgM类风湿因子，而在相应血清中未检测到。这些发现与以下观点一致，即冷球蛋白代表循环免疫复合物，在感染性心内膜炎患者有时出现的免疫后遗症发病机制中可能起重要作用。
