类风湿性滑液和冷沉淀物中的抗病毒抗体。
Antiviral antibodies in rheumatoid synovial fluid and cryoprecipitates.
作者信息
Cremer N E, Hurwitz D, Quismorio F P, Lennette E H, Friou G J
出版信息
Clin Exp Immunol. 1974 Sep;18(1):27-37.
Distribution of viral antibodies was examined by the indirect fluorescent antibody technique in specimens from rheumatoid arthritis and from systemic lupus erythematosus patients. Titres in sera from rheumatoid arthritis patients were usually equal to, or greater than, those in joint fluids. Viral antibodies were found in whole cryoprecipitates from joint fluids and in the IgG fractions of the cryoprecipitates. Anti-herpes simplex antibodies were most frequently found in cryoprecipitates and were at highest titre in sera and joint fluids. Anti-respiratory syncytial virus antibodies were next in frequency and in titre. No evidence was presented to support the concept of localized viral antibody synthesis in joints of rheumatoid arthritis patients. Serum antibody titres in systemic lupus erythematosus patients were similar to those in rheumatoid arthritis patients; however, viral antibodies were not found in the serum cryoprecipitates of systemic lupus erythematosus patients.
采用间接荧光抗体技术检测了类风湿性关节炎患者和系统性红斑狼疮患者标本中的病毒抗体分布情况。类风湿性关节炎患者血清中的抗体滴度通常等于或高于关节液中的滴度。在关节液的全冷沉淀物及其IgG组分中发现了病毒抗体。抗单纯疱疹病毒抗体在冷沉淀物中最常出现，且在血清和关节液中的滴度最高。抗呼吸道合胞病毒抗体的出现频率和滴度次之。没有证据支持类风湿性关节炎患者关节中存在局部病毒抗体合成的观点。系统性红斑狼疮患者的血清抗体滴度与类风湿性关节炎患者相似；然而，在系统性红斑狼疮患者的血清冷沉淀物中未发现病毒抗体。
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