Nåsell Ingemar
Department of Mathematics, The Royal Institute of Technology, S-100 44, Stockholm, Sweden.
Math Biosci. 2002 Jul-Aug;179(1):1-19. doi: 10.1016/s0025-5564(02)00098-6.
Stochastic models are established and studied for several endemic infections with demography. Approximations of quasi-stationary distributions and of times to extinction are derived for stochastic versions of SI, SIS, SIR, and SIRS models. The approximations are valid for sufficiently large population sizes. Conditions for validity of the approximations are given for each of the models. These are also conditions for validity of the corresponding deterministic model. It is noted that some deterministic models are unacceptable approximations of the stochastic models for a large range of realistic parameter values.
针对几种具有人口统计学特征的地方病感染建立并研究了随机模型。推导了SI、SIS、SIR和SIRS模型随机版本的拟平稳分布和灭绝时间的近似值。这些近似值对于足够大的种群规模是有效的。针对每个模型给出了近似值有效性的条件。这些也是相应确定性模型有效性的条件。需要注意的是,对于大范围的实际参数值,一些确定性模型是随机模型不可接受的近似。