Kaytor Michael D, Orr Harry T
Department of Laboratory Medicine and Pathology and Institute of Human Genetics, University of Minnesota, Mayo Mail Code 206, Minneapolis, Minnesota 55455, USA.
Curr Opin Neurobiol. 2002 Jun;12(3):275-8. doi: 10.1016/s0959-4388(02)00320-3.
Biochemical signaling pathways are known to have a critical role in neuronal development and function. A growing body of evidence is accumulating to suggest that signaling pathways also underlie neurodegeneration and neurodegenerative disease. One pathway with a prominent role in neurodegenerative disease is the signaling pathway in which the enzyme glycogen synthase kinase 3 (GSK3) is a key component. In vitro and in vivo evidence point to a key role for GSK3 in promoting neurodegeneration and in Alzheimer's disease plaque and neurofibrillary tangle formation. How GSK3 acts in this regard is still open to debate, but it may involve both extracellular and nuclear apoptotic activities.
已知生化信号通路在神经元发育和功能中起关键作用。越来越多的证据表明，信号通路也是神经退行性变和神经退行性疾病的基础。在神经退行性疾病中起重要作用的一条通路是糖原合酶激酶3（GSK3）作为关键成分的信号通路。体外和体内证据均表明，GSK3在促进神经退行性变以及阿尔茨海默病斑块和神经原纤维缠结形成方面起关键作用。GSK3在这方面的作用方式仍存在争议，但可能涉及细胞外和细胞核的凋亡活动。
