免疫致敏对博尔纳病的影响。
Effect of immune priming on Borna disease.
作者信息
Lewis A J, Whitton J L, Hatalski C G, Weissenböck H, Lipkin W I
机构信息
Department of Neurology, University of California, Irvine, California 92697-4292, USA.
出版信息
J Virol. 1999 Mar;73(3):2541-6. doi: 10.1128/JVI.73.3.2541-2546.1999.
Abstract
Borna disease virus (BDV) is a neurotropic virus with a broad host and geographic range. Lewis rats were immunized against BDV with a recombinant vaccinia virus expressing the BDV nucleoprotein and were later infected with BDV to evaluate protection against Borna disease (BD). Relative to animals that were not immunized, immunized animals had a decreased viral burden after challenge with infectious virus, more marked inflammation, and aggravated clinical disease. These data suggest that a more robust immune response in Borna disease can reduce viral load at the expense of increased morbidity.
摘要
博尔纳病病毒（BDV）是一种嗜神经性病毒，具有广泛的宿主范围和地理分布。用表达BDV核蛋白的重组痘苗病毒对Lewis大鼠进行BDV免疫，随后用BDV感染大鼠，以评估对博尔纳病（BD）的保护作用。与未免疫的动物相比，免疫动物在感染传染性病毒后病毒载量降低，炎症更明显，临床疾病加重。这些数据表明，博尔纳病中更强有力的免疫反应可降低病毒载量，但代价是发病率增加。
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