blaCTX-M-2位于一个不同寻常的1类整合子（In35）中，该整合子包含Orf513。
blaCTX-M-2 is located in an unusual class 1 integron (In35) which includes Orf513.
作者信息
Arduino Sonia M, Roy Paul H, Jacoby George A, Orman Betina E, Pineiro Silvia A, Centron Daniela
机构信息
Facultad de Medicina de la Universidad de Buenos Aires, Paraguay 2155 (1121)Capital Federal, Argentina.
出版信息
Antimicrob Agents Chemother. 2002 Jul;46(7):2303-6. doi: 10.1128/AAC.46.7.2303-2306.2002.
Abstract
Examination of the bla(CTX-M-2) gene in plasmid pMAR-12 by sequencing and PCR analysis revealed that the bla gene and the surrounding DNA, which is closely related (99% homology) to the Kluyvera ascorbata chromosomal DNA that contains the bla(KLUA-1) gene, are located in a complex sul1-type integron, termed In35, that includes Orf513. It is possible that bla(CTX-M-2) was acquired by plasmid pMAR-12 through an uncharacterized recombinational event in which Orf513 could be involved.
摘要
通过测序和PCR分析对质粒pMAR - 12中的bla(CTX - M - 2)基因进行检测，结果显示bla基因及其周围与含有bla(KLUA - 1)基因的抗坏血酸克吕沃尔氏菌染色体DNA密切相关（99%同源性）的DNA，位于一个复杂的sul1型整合子中，称为In35，该整合子包含Orf513。bla(CTX - M - 2)有可能是质粒pMAR - 12通过一个未明确的重组事件获得的，其中Orf513可能参与其中。
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