从一名患者身上连续分离出的产KPC-2的肺炎克雷伯菌和大肠埃希菌的全基因组序列
Complete Genome Sequences of and , KPC-2-Producers Serially Isolated from a Single Patient.
作者信息
Abed Jehane Y, Déraspe Maxime, Bérubé Ève, D'Iorio Matthew, Dewar Ken, Boissinot Maurice, Corbeil Jacques, Bergeron Michel G, Roy Paul H
机构信息
Centre de Recherche en Infectiologie, Centre de Recherche du CHU de Québec, Université Laval, 2705 boul. Laurier, Suite R-0709, Québec, QC G1V 4G2, Canada.
Département de Microbiologie et Immunologie, Pavillon Vandry, Université Laval, Québec, QC G1V 0A6, Canada.
出版信息
Antibiotics (Basel). 2021 Nov 18;10(11):1408. doi: 10.3390/antibiotics10111408.
Carbapenemase-producing including KPC-2 producers, have become a major clinical problem. During an outbreak in Quebec City, Canada, KPC-2-producing and were isolated from a patient six weeks apart. We determined their complete genome sequences. Both isolates carried nearly identical IncN2 plasmids with KPC-2 on a Tn element. Both strains also carried IncP1 plasmids, but that of did not carry a Beta-lactamase gene, whereas that of carried a second copy of on Tn. These results suggest recent plasmid transfer between the two species and a recent transposition event.
产碳青霉烯酶的菌株，包括产KPC-2的菌株，已成为一个主要的临床问题。在加拿大魁北克市的一次暴发期间，相隔六周从一名患者身上分离出产KPC-2的菌株。我们测定了它们的完整基因组序列。两个分离株都携带几乎相同的IncN2质粒，KPC-2位于一个转座子元件上。两个菌株还都携带IncP1质粒，但其中一个的IncP1质粒不携带β-内酰胺酶基因，而另一个的IncP1质粒在转座子上携带第二个KPC-2拷贝。这些结果表明这两个菌株之间最近发生了质粒转移以及最近发生了转座事件。
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