Lonart György
Department of Pathology and Anatomy, Eastern Virginia Medical School, PO Box 1980, Norfolk, VA 23501, USA.
Trends Neurosci. 2002 Jul;25(7):329-32. doi: 10.1016/s0166-2236(02)02193-8.
Pioneering work suggests that a synaptic active zone protein, RIM1, regulates both short- and long-term glutamatergic presynaptic plasticity at certain synapses. In short-term plasticity, RIM1 accelerates the priming of synaptic vesicles for fusion; by contrast, in long-term potentiation of mossy fiber synapses in the hippocampal CA3 region, phosphorylated RIM1 acts through an unknown molecular pathway to enhance release of the excitatory neurotransmitter glutamate.
开创性的研究表明，一种突触活性区蛋白RIM1在某些突触处调节谷氨酸能突触前的短期和长期可塑性。在短期可塑性中，RIM1加速突触小泡融合的启动；相比之下，在海马CA3区苔藓纤维突触的长期增强中，磷酸化的RIM1通过未知分子途径发挥作用，以增强兴奋性神经递质谷氨酸的释放。
