Pacher T, Seger C, Engelmeier D, Vajrodaya S, Hofer O, Greger H
Comparative and Ecological Phytochemistry Department, Institute of Botany, University of Vienna, Rennweg 14, A-1030 Wien, Austria.
J Nat Prod. 2002 Jun;65(6):820-7. doi: 10.1021/np0105073.
Fifteen new stilbenoids including 11 phenylbenzofurans, the stemofurans A-K (1-11), and four dihydrostilbenes, the stilbostemins A (15), C (17), E (19), and F (20), were isolated and identified from a methanolic extract of Stemona collinsae roots together with five known derivatives, the stilbenes pinosylvin (13) and 4'-methylpinosylvin (14), the dihydrostilbenes, stilbostemins B (16) and D (18), and the dihydrophenanthrene racemosol (12) as well as (+)-sesamin, coniferyl alcohol, and stigmasterol. Bioautographic tests with Cladosporium herbarum displayed antifungal activity for stilbenoids of all four structural types. Ten derivatives were tested against five microfungi using the microdilution technique linked with digital image analysis of germ tubes.
从柯氏百部根的甲醇提取物中分离并鉴定出15种新的芪类化合物，包括11种苯基苯并呋喃类化合物，即百部呋喃A - K（1 - 11），以及4种二氢芪类化合物，即芪百部素A（15）、C（17）、E（19）和F（20），同时还分离出5种已知衍生物，即芪类化合物白皮杉醇（13）和4'-甲基白皮杉醇（14）、二氢芪类化合物芪百部素B（16）和D（18）、二氢菲类化合物消旋索拉索醇（12）以及（+）-芝麻素、松柏醇和豆甾醇。对草本枝孢菌进行的生物自显影试验表明，所有四种结构类型的芪类化合物均具有抗真菌活性。使用与芽管数字图像分析相关的微量稀释技术，对10种衍生物针对5种微真菌进行了测试。
