Burleson Mary H, Poehlmann Kirsten M, Hawkley Louise C, Ernst John M, Berntson Gary G, Malarkey William B, Kiecolt-Glaser Janice K, Glaser Ronald, Cacioppo John T
Department of Social and Behavioral Sciences, Arizona State University West, Phoenix 85069-7100, USA.
Health Psychol. 2002 Jul;21(4):321-31. doi: 10.1037//0278-6133.21.4.321.
This study reviews prior research and reports longer-term consistency of stress-related immune variables in middle-aged and older women who performed mental math and speech tasks 2 times 1 year apart. Leukocyte subsets, mitogen-induced lymphocyte proliferation, and natural killer cell activity were measured at baseline, after tasks, and after 30-min recovery. Epstein-Barr virus (EBV) antibody titers were assessed at baseline. Pearson coefficients and standardized maximum-likelihood estimates of year-to-year covariances for leukocyte subsets and EBV titers showed moderately high to high baseline and posttask consistency and lower recovery consistency; consistency for other functional immune assays and reactivity scores for all variables was moderate to low. Results support longitudinal study of psychosocial context effects on tonic immune function and posttask scores.
本研究回顾了先前的研究，并报告了中年及老年女性在相隔1年进行2次心算和言语任务时，与压力相关的免疫变量的长期一致性。在基线、任务后和30分钟恢复后测量白细胞亚群、丝裂原诱导的淋巴细胞增殖和自然杀伤细胞活性。在基线时评估爱泼斯坦-巴尔病毒（EBV）抗体滴度。白细胞亚群和EBV滴度的逐年协方差的皮尔逊系数和标准化最大似然估计显示，基线和任务后一致性为中度高到高度，恢复一致性较低；所有变量的其他功能性免疫测定和反应性评分的一致性为中度到低度。结果支持对心理社会背景对静态免疫功能和任务后评分影响的纵向研究。
