Suditu G, Toma A, Voiculescu M
Centrul Medical Nicolina Iaşi, Universitatea de Medicină şi Farmacie Gr.T Popa Iaşi.
Rev Med Chir Soc Med Nat Iasi. 2001 Oct-Dec;105(4):760-2.
Topic immunotherapy in alopecia areata consist in a mild contact dermatitis with help of a chemical substances, with a high potency of sensitization, such as dinytroclorbenzenul (DNCB), squaric acid dibutylester (SADBE) and diphencypronil (DPCP). Eight patients with alopecia areata, 3 with mild form and 5 with severe form was treated with DPCP in acetone solution. We have obtained a positive result in 3 cases (37.5%), one with total regrows and 2 with partial regrows and a negative result in 5 cases, 3 with partial regrows and loss of the hair in other areas and 2 cases with no response after 24 weeks. We consider this method like an alternative therapy in severe alopecia areata resistant at other treatments.
斑秃的局部免疫疗法是借助具有高效致敏性的化学物质引发轻度接触性皮炎，如二硝基氯苯（DNCB）、二丁基酒石酸酯（SADBE）和二苯环丙烯酮（DPCP）。8例斑秃患者，3例轻度，5例重度，用丙酮溶液中的DPCP进行治疗。我们在3例患者（37.5%）中取得了阳性结果，1例完全再生，2例部分再生；5例为阴性结果，3例部分再生但其他部位脱发，2例在24周后无反应。我们认为这种方法可作为其他治疗无效的重度斑秃的替代疗法。
