Goffin Eric, Ziemons Eric, De Mol Patrick, de Madureira Maria do Céu, Martins Ana Paula, da Cunha Antonio Proença, Philippe Geneviève, Tits Monique, Angenot Luc, Frederich Michel
Planta Med. 2002 Jun;68(6):543-5. doi: 10.1055/s-2002-32552.
The antimalarial properties of Tithonia diversifolia, an Asteraceae traditionally used to treat malaria, were investigated in vitro against three strains of Plasmodium falciparum. The ether extract from aerial parts of the plant collected in São Tomé e Príncipe, demonstrated good antiplasmodial activity (IC 50 on FCA strain: 0.75 microg/ml). A bioassay guided fractionation of this extract led to the isolation of the known sesquiterpene lactone tagitinin C as an active component against Plasmodium (IC 50 on FCA strain: 0.33 microg/ml), but also possessing cytotoxic properties (IC 50 on HTC-116 cells: 0.706 microg/ml).
菊科植物异叶肿柄菊传统上用于治疗疟疾，对其抗疟特性进行了体外研究，以针对三种恶性疟原虫菌株。从圣多美和普林西比采集的该植物地上部分的乙醚提取物表现出良好的抗疟活性（对FCA菌株的IC50：0.75微克/毫升）。对该提取物进行生物测定导向的分级分离，得到了已知的倍半萜内酯tagitinin C，它是一种抗疟活性成分（对FCA菌株的IC50：0.33微克/毫升），但也具有细胞毒性（对HTC-116细胞的IC50：0.706微克/毫升）。
