Ferreira Farias Ana Luzia, Lobato Rodrigues Alex Bruno, Lopes Martins Rosany, de Menezes Rabelo Érica, Ferreira Farias Carlos Wagner, Moreira da Silva de Almeida Sheylla Susan
Laboratory of Pharmacognosy and Phytochemistry-Federal University of Amapá-Highway Jucelino Kubistichek, Km-02. Macapá, 68.902-280 Amapá, Brazil.
Pharmaceuticals (Basel). 2019 Mar 4;12(1):34. doi: 10.3390/ph12010034.
The present study aimed to evaluate the chemical composition, antioxidant potential, and the cytotoxic and antimicrobial activity of the essential oil of the plant species (Hemsl) A. Gray. The essential oil obtained was used to identify the chemical compounds present through the techniques of GC-MS and NMR. The antioxidant potential was calculated by the sequestration method of 2,2-diphenyl-1-picrylhydrazyl. For cytotoxic activity, the larval mortality of was evaluated. The main chemical constituents identified are pinene (9.9%), Limonene (5.40%), --ocimene (4.02%), -cymen-8-ol (3.0%), Piperitone (11.72%), -nerolidol (3.78%) and Spathulenol (10.8%). In the evaluation of the antimicrobial activity, bacterial strains of , and were used. The results showed that the bacterium were more susceptible to the presence of the essential oil, presenting minimal inhibitory concentration at the concentrations that were exposed. The essential oil presented antioxidant activity of 54.6% at the concentration of 5 mg·mL and provided a CI of 4.30. It was observed that the essential oil of this species was highly toxic against lavas, as its cytotoxic activity showed an LC of 3.11. Thus, it is concluded that oils are effective in inhibiting bacterial growth and reducing oxidative stress.
本研究旨在评估植物物种（Hemsl）A. Gray精油的化学成分、抗氧化潜力、细胞毒性和抗菌活性。所获得的精油用于通过气相色谱 - 质谱联用（GC-MS）和核磁共振（NMR）技术鉴定其中存在的化合物。抗氧化潜力通过2,2 - 二苯基 - 1 - 苦基肼自由基清除法计算。对于细胞毒性活性，评估了[具体物种]幼虫的死亡率。鉴定出的主要化学成分是蒎烯（9.9%）、柠檬烯（5.40%）、 - 罗勒烯（4.02%）、对伞花烃 - 8 - 醇（3.0%）、哌啶酮（11.72%）、 - 橙花叔醇（3.78%）和匙叶桉油烯醇（10.8%）。在抗菌活性评估中，使用了[具体细菌物种]、[具体细菌物种]和[具体细菌物种]的菌株。结果表明，[具体细菌物种]对精油的存在更敏感，在暴露的浓度下呈现出最低抑菌浓度。该精油在浓度为5 mg·mL时呈现出54.6%的抗氧化活性，且细胞毒性指数为4.30。观察到该物种的精油对[具体幼虫物种]幼虫具有高毒性，因为其细胞毒性活性显示致死浓度为3.11。因此，得出结论，[具体植物物种]精油在抑制细菌生长和降低氧化应激方面是有效的。
