Feil Denise, Chuang Kenneth, Sultzer David L
Division of Geriatric Psychiatry, VA Greater Los Angeles Healthcare System, CA 90073, USA.
Am J Geriatr Psychiatry. 2002 Jul-Aug;10(4):476-8.
The authors describe valproate-induced hyperammonemia and mental status changes in an 88-year-old man, the first known reported case in an elderly patient. They discuss this underrecognized complication of valproate use and the implications for treating elderly patients, in whom valproate use is increasing.
作者描述了一名88岁男性患者中丙戊酸盐诱发的高氨血症和精神状态改变，这是老年患者中已知的首例报告病例。他们讨论了这种丙戊酸盐使用中未被充分认识的并发症以及对正在增加使用丙戊酸盐的老年患者治疗的影响。
