Rejdak Robert, Toczołowski Jerzy, Solski Janusz, Duma Dariusz, Grieb Paweł
2nd Department of Ophthalmology, Medical University, Lublin, Poland.
Ophthalmic Res. 2002 May-Jun;34(3):146-9. doi: 10.1159/000063658.
Citicoline (exogenous cytidine-5'-diphosphocholine) was reported to enhance dopaminergic neurotransmission in the brain. A few clinical studies showed beneficial effects of this drug on the function of the visual pathway in patients with glaucoma or amblyopia. The present study was aimed at determining whether citicoline could influence retinal catecholamine levels in adult male Albino rabbits. The animals received the drug (50 mg/kg i.p., twice daily) or vehicle for 7 days, and retinal catecholamine concentrations were determined by HPLC. Compared to vehicle-treated controls, citicoline-treated animals displayed a significantly higher retinal dopamine concentration and a tendency toward an increase in adrenaline concentration, while the noradrenaline concentration remained unchanged. It is, therefore, conceivable that citicoline reinforces dopaminergic transmission in the retina.
据报道，胞磷胆碱（外源性胞苷-5'-二磷酸胆碱）可增强大脑中的多巴胺能神经传递。一些临床研究表明，这种药物对青光眼或弱视患者的视觉通路功能有有益影响。本研究旨在确定胞磷胆碱是否会影响成年雄性白化兔的视网膜儿茶酚胺水平。动物接受该药物（50mg/kg腹腔注射，每日两次）或赋形剂，持续7天，并用高效液相色谱法测定视网膜儿茶酚胺浓度。与接受赋形剂处理的对照组相比，接受胞磷胆碱处理的动物视网膜多巴胺浓度显著更高，肾上腺素浓度有增加趋势，而去甲肾上腺素浓度保持不变。因此，可以推测胞磷胆碱可增强视网膜中的多巴胺能传递。
