Upton A C
Environmental and Occupational Health Sciences Institute, New Brunswick, New Jersey 08901, USA.
Hum Exp Toxicol. 2002 Feb;21(2):111; discussion 113-4. doi: 10.1191/0960327102ht222oa.
In view of the diversity of biological responses and the extent to which many of them remain poorly elucidated, there is merit in the suggestion by Calabrese and Baldwin that the term 'hormesis' should be applicable to those adaptive responses that are characterized by biphasic dose-response relationships, without reference to any associated beneficial or harmful effects. Whether the dose-response relationships for radiation-induced mutations and chromosome aberrations are biphasic in nature is an important question that remains to be resolved.
鉴于生物反应的多样性以及其中许多反应仍未得到充分阐明的程度，卡拉布雷斯和鲍德温提出的“兴奋效应”一词应适用于那些以双相剂量反应关系为特征的适应性反应的建议是有价值的，而不考虑任何相关的有益或有害影响。辐射诱发的突变和染色体畸变的剂量反应关系本质上是否为双相，这是一个有待解决的重要问题。
