Kitchin K T
Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA.
Hum Exp Toxicol. 2002 Feb;21(2):105-6; discussion 113-4. doi: 10.1191/0960327102ht220oa.
A problem that hormesis has in being more scientifically accepted is (1) proving that only one mechanism accounts for both the 'beneficial' and 'toxic' parts of the biphasic dose-response curve and (2) giving substantial evidence against the interpretation that 'hormesis' is the sum of many different mechanisms which add up to either 'beneficial' or 'toxic' in two different parts of the dose-response curve. Hormesis may consist of a initial beneficial dose region where several mechanisms are operating (just for the sake of argument let us say 3 mechanisms) and the overall sum of these 3 mechanisms is 'beneficial' to the organism. At higher, toxic, doses, many more mechanisms are operating (just for the sake of argument let us say 8 mechanisms) and the sum of all these 8 mechanisms puts the organism in the 'toxic' part of the biphasic dose-response curve.
（1）证明只有一种机制能解释双相剂量反应曲线中“有益”和“有害”部分；（2）提供充分证据反驳那种认为“兴奋效应”是许多不同机制之和的解释，即在剂量反应曲线的两个不同部分，这些机制相加分别产生“有益”或“有害”的效果。兴奋效应可能包括一个初始有益剂量区域，此时有几种机制在起作用（为便于讨论，假设为3种机制），这3种机制的总体效果对生物体是“有益的”。在更高的、有毒的剂量下，有更多机制在起作用（为便于讨论，假设为8种机制），这8种机制的总和使生物体处于双相剂量反应曲线的“有害”部分。
