Martin A R, Sornay-Rendu E, Chandler J M, Duboeuf F, Girman C J, Delmas P D
Merck Research Laboratories, West Point, PA, USA.
Bone. 2002 Jul;31(1):32-6. doi: 10.1016/s8756-3282(02)00787-1.
Although the long-term outcomes of osteoporosis (Op) such as fracture, kyphosis, and pain are well known, the physical, psychological, and social consequences, beyond fracture and pain, are less clear. The Osteoporosis-targeted Quality-of-life (OPTQoL) questionnaire aimed at assessing the physical difficulty, fears, and adaptations to one's daily life was developed as a cross-sectional instrument to characterize the burden of Op within a community. The purpose of this study was to assess the impact of Op and related factors on community women participating in the OFELY study in France. Femoral neck bone mineral density (BMD) and OPTQoL questionnaire data were collected from women randomly selected from a large insurance company. Data were obtained for 756 women (mean age 59 years, range 36-92), most of whom were white. Women were classified into five groups based on the extent of physical manifestations and family history of Op. Women who had prior fractures, height loss, and/or kyphosis or both reported greater physical difficulty, more adaptations to their lives, and greater fears than women reporting no such changes. Scores on the Physical Difficulty domain, however, did not differ significantly based on BMD alone (BMD T score <or=2.5), after controlling for age and self-reported arthritis. The negative impact of Op on quality-of-life (QoL) seems to be more related to the physical manifestations of Op than to bone density levels. Recognition of the impact of Op-related factors on QoL may help health-care providers more fully appreciate the importance of prevention and treatment.
尽管骨质疏松症（Op）的长期后果，如骨折、脊柱后凸和疼痛广为人知，但除骨折和疼痛之外的身体、心理和社会后果却不太明确。骨质疏松症针对性生活质量（OPTQoL）问卷旨在评估身体困难、恐惧以及对日常生活的适应情况，它是作为一种横断面工具开发的，用于描述社区内骨质疏松症的负担。本研究的目的是评估骨质疏松症及相关因素对参与法国OFELY研究的社区女性的影响。从一家大型保险公司随机选取的女性中收集股骨颈骨密度（BMD）和OPTQoL问卷数据。获得了756名女性的数据（平均年龄59岁，范围36 - 92岁），其中大多数是白人。根据骨质疏松症的身体表现程度和家族史，将女性分为五组。与未报告此类变化的女性相比，有既往骨折、身高降低和/或脊柱后凸或两者皆有的女性报告了更大的身体困难、更多对生活的适应情况以及更多恐惧。然而，在控制年龄和自我报告的关节炎后，仅基于骨密度（骨密度T值≤2.5），身体困难领域的得分并无显著差异。骨质疏松症对生活质量（QoL）的负面影响似乎更多地与骨质疏松症的身体表现有关，而非与骨密度水平有关。认识到骨质疏松症相关因素对生活质量的影响可能有助于医疗保健提供者更充分地认识到预防和治疗的重要性。
