Lydick E, Zimmerman S I, Yawn B, Love B, Kleerekoper M, Ross P, Martin A, Holmes R
Merck Research Laboratories, West Point, Pennsylvania, USA.
J Bone Miner Res. 1997 Mar;12(3):456-63. doi: 10.1359/jbmr.1997.12.3.456.
We report the development and validation of an osteoporosis-targeted quality of life questionnaire to measure the impact of the disease in the general population. From multiple focus groups with women with osteoporosis, healthy women at risk for osteoporosis, spouses and relatives of women with osteoporosis, and health care providers, we identified over 300 potential items related to the disease. A lengthy questionnaire incorporated these items and was administered to a second large study cohort of 222 women with clinical osteoporosis (history of fracture, significant height loss, and/or kyphosis); 101 women with known low bone mineral density levels that would categorize them as osteoporotic but who had not yet shown obvious physical manifestations of the disease; and 142 women with other conditions (such as arthritis, cancer, depression) expected to also have an impact on quality of life. Final items from among the original 300 were chosen for their demonstrated relationship with osteoporosis as measured by clinical manifestations and low bone density and with quality of life measured by a standard generic questionnaire, the SF-36. The final questionnaire contains 26 scored items in three domains-physical activity, adaptations, and fears- and six nonscored questions relating to osteoporotic changes and diagnosis. This instrument is unique among osteoporosis-targeted questionnaires in that it attempts to measure the total impact of the disease on quality of life within a population at a single point in time.
我们报告了一份针对骨质疏松症的生活质量调查问卷的开发与验证情况，该问卷旨在衡量该疾病对普通人群的影响。通过与患有骨质疏松症的女性、有骨质疏松症风险的健康女性、患有骨质疏松症女性的配偶及亲属以及医疗服务提供者进行多次焦点小组讨论，我们确定了300多个与该疾病相关的潜在项目。一份冗长的问卷纳入了这些项目，并施用于第二个大型研究队列，其中包括222名患有临床骨质疏松症（有骨折史、明显身高降低和/或脊柱后凸）的女性；101名已知骨矿物质密度水平低、可归类为骨质疏松症但尚未表现出该疾病明显身体症状的女性；以及142名患有其他疾病（如关节炎、癌症、抑郁症）且预计也会对生活质量产生影响的女性。从最初的300个项目中最终选取的项目，是因为它们与通过临床表现和低骨密度衡量的骨质疏松症以及通过标准通用问卷SF - 36衡量的生活质量之间存在已证实的关系。最终问卷包含三个领域（身体活动、适应情况和恐惧）中的26个计分项目以及六个与骨质疏松症变化和诊断相关的不计分问题。该工具在针对骨质疏松症的调查问卷中是独一无二的，因为它试图在某一时刻衡量该疾病对某一人群生活质量的总体影响。
