Rajabi Marziyeh, Ostovar Afshin, Sari Ali Akbari, Sajjadi-Jazi Sayed Mahmoud, Mousavi Abdoreza, Larijani Bagher, Fahimfar Noushin, Daroudi Rajabali
Vice-Chancellor for Public Health, Bushehr University of Medical Sciences, Bushehr, Iran.
Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
J Bone Metab. 2023 Feb;30(1):37-46. doi: 10.11005/jbm.2023.30.1.37. Epub 2023 Feb 28.
This study aimed to measure the health-related quality of life (HRQOL) of patients with osteoporosis with and without fractures in Tehran, the capital city of Iran.
We surveyed a sample of 478 patients with osteoporosis aged over 50 years. Participants with fractures included patients referred to hospitals due to osteoporotic fractures which were alive 6 months after the fracture. Participants without fractures were randomly selected from patients with a definite diagnosis of osteoporosis admitted to 3 outpatient clinics in Tehran. Data were collected using the EuroQol 5-dimensional 5-level questionnaire. Statistical differences between patients with and without fracture were tested with Pearson's χ2 test, Student's t-test, and the Mann-Whitney U-test. The association between HRQOL and other variables was evaluated using a multiple linear regression model.
The patients' mean age±standard deviation was 67.3±11.9 years, and 74.1% were women. One hundred and seventeen (23%) patients had hip fractures, 56 (11%) had vertebral fractures, 127 (25%) had forearm fractures, and 178 (40%) had no fractures. The median (interquartile range) values of HRQOL scores of those with hip, vertebral, and forearm fractures and those with no history of fracture were 0.53 (0.22), 0.60 (0.28), 0.64 (0.26), and 0.64 (0.27), respectively. The multiple regression model revealed a significant relationship between the HRQOL scores and sex, marital status, employment status, presence of any chronic illness in addition to osteoporosis, and type of fracture.
Osteoporosis and its related fractures can reduce the HRQOL.
本研究旨在衡量伊朗首都德黑兰有骨折和无骨折的骨质疏松症患者的健康相关生活质量（HRQOL）。
我们对478名年龄超过50岁的骨质疏松症患者进行了抽样调查。有骨折的参与者包括因骨质疏松性骨折而转诊至医院且骨折后存活6个月的患者。无骨折的参与者是从德黑兰3家门诊诊所确诊为骨质疏松症的患者中随机选取的。使用欧洲五维健康量表（EuroQol 5-dimensional 5-level questionnaire）收集数据。采用Pearson卡方检验、Student t检验和Mann-Whitney U检验来检验有骨折和无骨折患者之间的统计学差异。使用多元线性回归模型评估HRQOL与其他变量之间的关联。
患者的平均年龄±标准差为67.3±11.9岁，74.1%为女性。117名（23%）患者发生髋部骨折，56名（11%）发生椎体骨折，127名（25%）发生前臂骨折，178名（40%）无骨折。髋部、椎体和前臂骨折患者以及无骨折病史患者的HRQOL得分中位数（四分位间距）分别为0.53（0.22）、0.60（0.28）、0.64（0.26）和0.64（0.27）。多元回归模型显示，HRQOL得分与性别、婚姻状况、就业状况、除骨质疏松症外是否存在任何慢性病以及骨折类型之间存在显著关系。
骨质疏松症及其相关骨折会降低健康相关生活质量。
