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来自口腔拟杆菌、具核梭杆菌和微小韦荣球菌的脂多糖对人补体的激活作用。

Human complement activation by lipopolysaccharides from bacteroides oralis, fusobacterium nucleatum, and veillonella parvula.

作者信息

Nygren H, Dahlén G, Nilsson L A

出版信息

Infect Immun. 1979 Nov;26(2):391-6. doi: 10.1128/iai.26.2.391-396.1979.

DOI:10.1128/iai.26.2.391-396.1979
PMID:121108
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC414626/
Abstract

The properties of different lipopolysaccharide (LPS) preparations to induce C3 conversion in human serum was studied by means of crossed immunoelectrophoresis. C3 conversion by the alternative pathway was evaluated after calcium depletion, and lipid A-dependent activation was measured by means of inhibition with polymyxin B sulfate. LPS from Bacteroides oralis converted Co mainly via the alternative pathway, whereas LPS from Fusobacterium nucleatum and Veillonella parvula const pronounced lipid A-dependent conversion. The results are discussed in relation to the chemical composition of the LPS preparations.

摘要

通过交叉免疫电泳研究了不同脂多糖（LPS）制剂在人血清中诱导C3转化的特性。在耗尽钙后评估通过替代途径的C3转化，并通过硫酸多粘菌素B抑制来测量脂多糖A依赖性激活。口腔拟杆菌的LPS主要通过替代途径转化C3，而具核梭杆菌和小韦荣球菌的LPS则表现出明显的脂多糖A依赖性转化。结合LPS制剂的化学成分对结果进行了讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a417/414626/05cf25df68e8/iai00191-0004-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a417/414626/0bef729196b6/iai00191-0003-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a417/414626/57f24be6696a/iai00191-0004-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a417/414626/05cf25df68e8/iai00191-0004-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a417/414626/0bef729196b6/iai00191-0003-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a417/414626/57f24be6696a/iai00191-0004-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a417/414626/05cf25df68e8/iai00191-0004-b.jpg

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