Dahlén G
Scand J Dent Res. 1980 Apr;88(2):122-9. doi: 10.1111/j.1600-0722.1980.tb01203.x.
Lipopolysaccharides (LPS) prepared from one strain of Fusobacterium nucleatum and one strain of Bacteroides oralis were examined for immunological responses in rats. The LPS were applied to the pulp chamber of the two mandibular incisors. Using the plaque forming cell (PFC) method both antigens showed a rapid IgM response in the spleen, and a slower one in the submandibular lymph nodes. In comparison with the IgM response, the IgG response was somewhat slower and weaker for LPS of Bacteroides, while for LPS of Fusobacterium it was hardly detectable. After about 3 weeks both antigens gave a significant antibody titer in serum. The results showed that locally applied antigens of oral microorganisms can stimulate to an immune response both in the lymph nodes and the spleen resulting in circulating antibodies. The nature of this response is dependent on the chemical characteristics of the LPS-antigen.
对从具核梭杆菌的一个菌株和口腔拟杆菌的一个菌株制备的脂多糖（LPS）进行了大鼠免疫反应检测。将这些LPS应用于两颗下颌切牙的髓腔。采用空斑形成细胞（PFC）法，两种抗原在脾脏中均呈现快速的IgM反应，而在下颌下淋巴结中的反应较慢。与IgM反应相比，口腔拟杆菌LPS的IgG反应稍慢且较弱，而具核梭杆菌LPS的IgG反应几乎检测不到。约3周后，两种抗原在血清中均产生显著的抗体滴度。结果表明，局部应用的口腔微生物抗原可刺激淋巴结和脾脏产生免疫反应，从而产生循环抗体。这种反应的性质取决于LPS抗原的化学特性。
