Leach M C, Bowell V A, Allan T F, Morton D B
Centre for Biomedical Ethics, The Medical School, University of Birmingham, Edgbaston.
Vet Rec. 2002 Jun 29;150(26):808-15. doi: 10.1136/vr.150.26.808.
The distress associated with the induction of anaesthesia with halothane, isoflurane, enflurane and carbon dioxide was investigated in rats and mice by measuring the level of aversion they displayed on exposure to low, medium and high concentrations of these agents. The animals were exposed to each agent in a test chamber containing air or gas mixtures, which they were able to enter and leave at will, and the level of aversion was assessed in terms of the initial withdrawal and total dwelling times in the chamber. Comparisons between the anaesthetic and air-control treatments indicated that concentrations of the agents recommended for the rapid and efficient induction of anaesthesia were associated with some degree of aversion. Carbon dioxide was by far the most aversive gas for both rats and mice, with the least aversive being halothane for rats, and halothane and enflurane for mice. With all the anaesthetics, the level of aversion increased as the concentration increased.
通过测量大鼠和小鼠在接触低、中、高浓度的氟烷、异氟烷、恩氟烷和二氧化碳时表现出的厌恶程度，研究了这些药物诱导麻醉时产生的不适。将动物置于装有空气或气体混合物的测试箱中，使其能够自由进出，通过测量动物最初撤离测试箱的时间和在箱内停留的总时间来评估厌恶程度。麻醉剂与空气对照处理之间的比较表明，推荐用于快速有效诱导麻醉的药物浓度与一定程度的厌恶有关。二氧化碳对大鼠和小鼠来说是最令人厌恶的气体，对大鼠来说最不令人厌恶的是氟烷，对小鼠来说是氟烷和恩氟烷。对于所有麻醉剂，厌恶程度随着浓度的增加而增加。
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