Fukai Tohru, Folz Rodney J, Landmesser Ulf, Harrison David G
Department of Medicine, Division of Cardiology, Emory University, 1639 Pierce Drive, WMB 319, Atlanta, GA 30322, USA.
Cardiovasc Res. 2002 Aug 1;55(2):239-49. doi: 10.1016/s0008-6363(02)00328-0.
Excessive production and/or inadequate removal of reactive oxygen species, especially superoxide anion (O(2)(-)), have been implicated in the pathogenesis of many cardiovascular diseases, including atherosclerosis, hypertension, diabetes, and in endothelial dysfunction by decreasing nitric oxide (NO) bioactivity. Since the vascular levels of O(2)(-) are regulated by the superoxide dismutase (SOD) enzymes, a role of SOD in the cardiovascular disease is of substantial interest. Particularly, a major form of SOD in the vessel wall is the extracellular SOD (ecSOD). This review will discuss the characteristics of ecSOD and the role of ecSOD in cardiovascular diseases.
活性氧的过度产生和/或清除不足，尤其是超氧阴离子（O(2)(-)），已被认为与许多心血管疾病的发病机制有关，包括动脉粥样硬化、高血压、糖尿病，以及通过降低一氧化氮（NO）生物活性导致的内皮功能障碍。由于血管中O(2)(-)的水平受超氧化物歧化酶（SOD）调节，SOD在心血管疾病中的作用备受关注。特别是，血管壁中SOD的主要形式是细胞外SOD（ecSOD）。本综述将讨论ecSOD的特性及其在心血管疾病中的作用。
