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严重畸形精子症的超微结构特征及卵胞浆内单精子注射治疗:两例圆头精子症患者报告

Ultrastructural features and ICSI treatment of severe teratozoospermia: report of two human cases of globozoospermia.

作者信息

Nardo Luciano G, Sinatra Fulvia, Bartoloni Giovanni, Zafarana Salvatore, Nardo Filadelfo

机构信息

Department of Obstetrics and Gynaecology and Radiological Sciences, Centre for Reproductive Medicine and Infertility, Ascoli-Tomaselli Hospital, University of Catania, Catania 95125, Italy.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2002 Aug 5;104(1):40-2. doi: 10.1016/s0301-2115(01)00602-9.

Abstract

Abnormal sperm morphology is associated with male infertility. We describe two human cases of globozoospermia (round-headed spermatozoa) together with fine diagnosis and proposed treatment. Scanning and transmission electron microscopy (SEM and TEM) were performed to identify the ultrastructural features. Female partners underwent ovarian hyperstimulation and intracytoplasmic sperm injection (ICSI). Fertilized oocytes were transferred 36 h later. One couple had a healthy live-birth. Ultrastructural analysis may help to diagnose sperm morphology and identify those which will respond to treatment.

摘要

异常精子形态与男性不育有关。我们描述了两例圆头精子症(圆头精子)的人类病例,并进行了详细诊断和提出了治疗方案。进行了扫描和透射电子显微镜检查(SEM和TEM)以确定超微结构特征。女性伴侣接受了卵巢过度刺激和卵胞浆内单精子注射(ICSI)。36小时后移植受精卵。一对夫妇生下了一个健康的活产婴儿。超微结构分析可能有助于诊断精子形态并识别那些对治疗有反应的精子。

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