Dirican Enver K, Isik Ahmet, Vicdan Kubilay, Sozen Eran, Suludere Zekiye
Department of Embryology, Private Ankara IVF Center, Ankara 06460, Turkey.
Asian J Androl. 2008 Mar;10(2):332-6. doi: 10.1111/j.1745-7262.2008.00248.x. Epub 2007 Dec 20.
We report the successful outcome of intracytoplasmic sperm injection (ICSI) treatment in two siblings with familial globozoospermia. After controlled ovarian hyperstimulation and oocyte pick-up, retrieved oocytes were mechanically activated before ICSI and a fertilization rate of 33.3% was achieved in the first case. The second couple underwent ICSI without oocyte activation and a 9.1% fertilization rate was obtained. The transfer of two grade I embryos in the first couple and one grade I embryo in the second couple resulted in clinical pregnancies with healthy livebirths. It was concluded that the main problem of cases with globozoospermia is a low fertilization rate, and even though ICSI and oocyte activation can increase this rate it is not necessarily needed to achieve a pregnancy.
我们报告了两例患有家族性圆头精子症的兄弟姐妹接受卵胞浆内单精子注射（ICSI）治疗的成功结果。在控制性卵巢过度刺激和取卵后，获取的卵母细胞在ICSI前进行了机械激活，第一例的受精率为33.3%。第二对夫妇未进行卵母细胞激活而接受了ICSI，受精率为9.1%。第一对夫妇移植了两枚一级胚胎，第二对夫妇移植了一枚一级胚胎，均获得临床妊娠并产下健康活婴。结论是，圆头精子症病例的主要问题是受精率低，尽管ICSI和卵母细胞激活可以提高受精率，但实现妊娠不一定需要这样做。
