NMDA受体依赖性双向突触可塑性的统一模型。
A unified model of NMDA receptor-dependent bidirectional synaptic plasticity.
作者信息
Shouval Harel Z, Bear Mark F, Cooper Leon N
机构信息
Institute for Brain and Neural Systems, Brown University, Providence, RI 02912, USA.
出版信息
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10831-6. doi: 10.1073/pnas.152343099. Epub 2002 Jul 22.
Abstract
Synapses in the brain are bidirectionally modifiable, but the routes of induction are diverse. In various experimental paradigms, N-methyl-d-aspartate receptor-dependent long-term depression and long-term potentiation have been induced selectively by varying the membrane potential of the postsynaptic neurons during presynaptic stimulation of a constant frequency, the rate of presynaptic stimulation, and the timing of pre- and postsynaptic action potentials. In this paper, we present a mathematical embodiment of bidirectional synaptic plasticity that is able to explain diverse induction protocols with a fixed set of parameters. The key assumptions and consequences of the model can be tested experimentally; further, the model provides the foundation for a unified theory of N-methyl-d-aspartate receptor-dependent synaptic plasticity.
摘要
大脑中的突触具有双向可塑性，但其诱导途径多种多样。在各种实验范式中，通过在恒定频率的突触前刺激、突触前刺激速率以及突触前和突触后动作电位的时间过程中改变突触后神经元的膜电位，已选择性地诱导出了N-甲基-D-天冬氨酸受体依赖性长时程抑制和长时程增强。在本文中，我们提出了一种双向突触可塑性的数学模型，该模型能够用一组固定的参数解释各种诱导方案。该模型的关键假设和结果可以通过实验进行检验；此外，该模型为N-甲基-D-天冬氨酸受体依赖性突触可塑性的统一理论提供了基础。
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