Tanaka Junko, Koshimura Kunio, Tsumori Michihiro, Murakami Yoshio, Kato Yuzuru
Department of Medicine, Shimane Medical University, Izumo, Japan.
Acta Biochim Pol. 2002;49(1):227-32.
It has been reported that concentrations of neopterin in the urine are changed according to the host immunological conditions. In the present study, we measured urinary concentration of neopterin in patients with malignant hematological disorders and investigated the relationship between urinary neopterin levels and laboratory indices for cellular immunity. Urine neopterin levels were correlated with serum sIL-2R levels in the patients with malignant lymphoma, and inversely correlated with lymphocyte reactivity with ConA in the patients with acute myelocytic leukemia. However, no significant correlation was observed between urine neopterin levels and lymphocyte reactivity with phytohemagglutinin and pokeweed mitogen, CD4/8 ratio, CD56+ 16+ subset or serum IFN-gamma levels. In the patients with malignant lymphoma, parallel changes in serum sIL-2R and urine neopterin were observed. The presented results suggest that urine neopterin levels are related to the activation of T cells in malignant lymphoma.
据报道，尿中新蝶呤的浓度会根据宿主的免疫状况而变化。在本研究中，我们测量了恶性血液系统疾病患者尿中新蝶呤的浓度，并研究了尿中新蝶呤水平与细胞免疫实验室指标之间的关系。恶性淋巴瘤患者的尿新蝶呤水平与血清可溶性白细胞介素-2受体（sIL-2R）水平相关，而急性髓细胞白血病患者的尿新蝶呤水平与淋巴细胞对刀豆蛋白A（ConA）的反应性呈负相关。然而，尿新蝶呤水平与淋巴细胞对植物血凝素和商陆有丝分裂原的反应性、CD4/8比值、CD56 + 16 +亚群或血清干扰素-γ水平之间未观察到显著相关性。在恶性淋巴瘤患者中，观察到血清sIL-2R和尿新蝶呤的平行变化。所呈现的结果表明，尿新蝶呤水平与恶性淋巴瘤中T细胞的激活有关。
