对映-曲洛巴烷-3β-醇，一种来自赞比亚巴豆的新型细胞毒性二萜。
ent-trachyloban-3beta-ol, a new cytotoxic diterpene from Croton zambesicus.
作者信息
Block S, Stévigny C, De Pauw-Gillet M-C, de Hoffmann E, Llabrès G, Adjakidjé V, Quetin-Leclercq J
出版信息
Planta Med. 2002 Jul;68(7):647-9. doi: 10.1055/s-2002-32903.
The dichloromethane extract of leaves of Croton zambesicus (Euphorbiaceae) showing in vitro cytotoxicity against human cervix carcinoma cells was investigated in order to identify its active compounds. A bio-guided fractionation by HSCCC followed by MPLC led us to isolate a trachylobane diterpene, ent-trachyloban-3beta-ol, with cytotoxic properties (IC50 on HeLa cells = 7.3 microg/ml). This is the first report on the cytotoxicity of a trachylobane diterpene.
为了鉴定其活性化合物，对显示出对人宫颈癌细胞具有体外细胞毒性的赞比亚巴豆（大戟科）叶的二氯甲烷提取物进行了研究。通过高速逆流色谱（HSCCC）随后进行中压液相色谱（MPLC）的生物导向分级分离，使我们分离出一种具有细胞毒性的trachylobane二萜，对映- trachyloban - 3β-醇（IC50对HeLa细胞= 7.3微克/毫升）。这是关于trachylobane二萜细胞毒性的首次报道。
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