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出生队列研究(BAMSE)中的过敏环境风险因素与社会经济地位

Environmental risk factors for allergy and socioeconomic status in a birth cohort (BAMSE).

作者信息

Lannerö E, Kull I, Wickman M, Pershagen G, Nordvall S L

机构信息

Department of Environmental Health, Astrid Lindgren's Children's Hospital, Karolinska Hospital, Sweden.

出版信息

Pediatr Allergy Immunol. 2002 Jun;13(3):182-7. doi: 10.1034/j.1399-3038.2002.01055.x.

Abstract

Associations between parental educational level and possible risk factors for atopic disease during the first months of life were explored in a cohort of 4089 neonate children born 1994-96 in Stockholm, Sweden. Reports concerning a number of life style factors during pregnancy and after the baby was born were obtained by questionnaire. There was a strong negative association between duration of education and maternal smoking during pregnancy, parental smoking after the baby was born and keeping of cat and dog (p-trend < 0.001), respectively. For example, smoking during pregnancy was reported by 6.7% (95% CI 5.5-7.9) of mothers with college or university degree and by 22.2% (95% CI 20.1-24.5) of those with the shortest education. Indicators of dampness and poor ventilation were also more common in homes of those with the shortest education. The results show that the educational level has an influence on risk factors for development of atopic disease in childhood and indicates a need of deeper understanding of life style in different socioeconomic groups. The data also indicate that various possible confounding factors need to be thoroughly investigated when analysing studies of risk factors for allergic disease in childhood.

摘要

在瑞典斯德哥尔摩,对1994年至1996年出生的4089名新生儿队列进行了研究,探讨了父母教育水平与出生后最初几个月内特应性疾病可能的风险因素之间的关联。通过问卷调查获取了有关孕期及婴儿出生后一些生活方式因素的报告。教育年限与孕期母亲吸烟、婴儿出生后父母吸烟以及养猫和狗之间分别存在强烈的负相关(p趋势<0.001)。例如,大学学历的母亲中6.7%(95%置信区间5.5 - 7.9)报告孕期吸烟,而受教育年限最短的母亲中这一比例为22.2%(95%置信区间20.1 - 24.5)。潮湿和通风不良的指标在受教育年限最短者的家庭中也更为常见。结果表明,教育水平对儿童特应性疾病发展的风险因素有影响,这表明需要更深入地了解不同社会经济群体的生活方式。数据还表明,在分析儿童过敏性疾病风险因素的研究时,需要对各种可能的混杂因素进行全面调查。

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