疾病中的伴侣蛋白：机制、模型与治疗方法
Chaperonins in disease: mechanisms, models, and treatments.
作者信息
Ranford J C, Henderson B
机构信息
Cellular Microbiology Research Group, Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, UK.
出版信息
Mol Pathol. 2002 Aug;55(4):209-13. doi: 10.1136/mp.55.4.209.
Abstract
Chaperonins are oligomeric proteins that assist in the folding of nascent or denatured proteins. Bacterial chaperonins are strongly immunogenic and can cause tissue pathology. They have been implicated in infection, autoimmune disease, and idiopathic or multifactorial diseases, such as arthritis and atherosclerosis. Chaperonin 60 proteins are also involved in prion diseases. In the past few years, much progress has been made in unravelling the involvement of various bacterial and mammalian chaperonin 60 (Cpn 60 or hsp 60) proteins in such diseases, and in proposing mechanisms for their biological actions, although we are still some way from a full understanding of chaperonin action that might lead to immunotherapeutic approaches. This review focuses on the current knowledge of the roles of Cpn 60 in the pathology of infectious and immune diseases, and discusses models for the actions of this molecule. Some potential therapeutic strategies will also be reviewed.
摘要
伴侣蛋白是一种寡聚蛋白，可协助新生或变性蛋白质的折叠。细菌伴侣蛋白具有很强的免疫原性，可导致组织病变。它们与感染、自身免疫性疾病以及特发性或多因素疾病（如关节炎和动脉粥样硬化）有关。伴侣蛋白60也与朊病毒疾病有关。在过去几年中，在揭示各种细菌和哺乳动物伴侣蛋白60（Cpn 60或hsp 60）在这些疾病中的作用以及提出其生物学作用机制方面取得了很大进展，尽管我们距离全面理解可能导致免疫治疗方法的伴侣蛋白作用仍有一段路要走。本综述重点关注Cpn 60在感染性和免疫性疾病病理学中的作用的当前知识，并讨论该分子的作用模型。还将综述一些潜在的治疗策略。
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