Vereczkey L, Bianchetti G, Garattini S, Morselli P L
Psychopharmacologia. 1975 Dec 31;45(2):225-7. doi: 10.1007/BF00429065.
Nomifensine pharmacokinetics were determined in healthy volunteers after the oral administration of 50 mg of the drug. Peak plasma levels of 95-177 ng/ml were attained within 1 to 4 hrs, and the apparent plasma half-lives ranged from 3.3 to 4.9 hrs. Assuming 100% bioavailability the drug has a relatively large apparent volume of distribution. From these findings it appears that the pharmacokinetics profile of nomifensine is considerably different from those of other known antidepressants. Implications for dosages schedules are discussed.
在健康志愿者口服50毫克诺米芬辛后测定了其药代动力学。服药后1至4小时内血浆峰值水平达到95 - 177纳克/毫升，表观血浆半衰期为3.3至4.9小时。假设生物利用度为100%，该药物的表观分布容积相对较大。从这些研究结果来看，诺米芬辛的药代动力学特征与其他已知抗抑郁药有很大不同。文中讨论了给药方案的影响因素。
