气相色谱法测定人血浆中去甲丙咪嗪的含量。
Gas chromatographic method for the determination of nomifensine in human plasma.
作者信息
Vereczkey L, Bianchetti G, Rovei V, Frigerio A
出版信息
J Chromatogr. 1976 Jan 21;116(2):451-6. doi: 10.1016/s0021-9673(00)89916-1.
PMID:1245582
Abstract
An analytical method based on solvent extraction, formation of a fluorinated derivative and quantitation by gas-liquid chromatography using an electron capture detector has been developed for the determination of nomifensine in biological fluids. The specificity (controlled by mass spectrometry) and the sensitivity appear to be satisfactory for drug level measurements in human body fluids. Its relative simplicity in fact permits its use in serial analysis.
摘要
已开发出一种基于溶剂萃取、形成氟化衍生物并使用电子捕获检测器通过气液色谱法定量的分析方法，用于测定生物流体中的诺米芬辛。该方法的特异性（通过质谱法控制）和灵敏度对于人体体液中的药物水平测量似乎是令人满意的。其相对简单性实际上使其可用于系列分析。
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