Weidmann P, Steffen F, Beretta-Piccoli C, Blumberg A, Bühler F R, Reubi F C
Schweiz Med Wochenschr. 1975 Dec 20;105(51):1779-80.
Plasma renin activity was found to correlate inversely with exchangeable sodium or blood volume in both normotensive and hypertensive hemodialysis patients. However, in the hypertensive patients mean circulating renin for any given sodium/volume state was markedly higher than in normotensive patients or normal subjects. Blood pressure correlated more closely with the products of circulating renin and exchangeable sodium (r = 0.55; p less than 0.001) or blood volume (r = 0.43; p less than 0.001) than with the individual components (r less than or equal to 0.39); multiple regression analysis including duration of previous hypertension as a second independent variable further improved these correlations (r = 0.66 and r = 0.63 respectively). This suggests that the sodium/volume state, circulating renin and vascular changes resulting from previous hypertension may be important complementary determinants of blood pressure in hemodialysis patients.
在正常血压和高血压血液透析患者中，发现血浆肾素活性与可交换钠或血容量呈负相关。然而，对于任何给定的钠/容量状态，高血压患者的平均循环肾素水平明显高于正常血压患者或正常受试者。血压与循环肾素和可交换钠的乘积（r = 0.55；p < 0.001）或血容量（r = 0.43；p < 0.001）的相关性比与单个成分的相关性更密切（r ≤ 0.39）；将既往高血压持续时间作为第二个自变量的多元回归分析进一步改善了这些相关性（分别为r = 0.66和r = 0.63）。这表明钠/容量状态、循环肾素以及既往高血压导致的血管变化可能是血液透析患者血压的重要互补决定因素。
