人乳腺癌中的前列腺素合成酶和前列腺素E2水平

Prostaglandin synthetase and prostaglandin E2 levels in human breast carcinoma.

作者信息

Kibbey W E, Bronn D G, Minton J P

出版信息

Prostaglandins Med. 1979 Feb;2(2):133-9. doi: 10.1016/0161-4630(79)90048-x.

DOI:10.1016/0161-4630(79)90048-x

Abstract

Prostaglandin synthetase activity and tissue prostaglandin E2 levels were measured in 53 human breast carcinoma specimens. Each set of data is log-normally distributed. There is a weak but statistically significant correlation between prostaglandin synthetase activity and tissue prostaglandin E2 levels of individual specimens. In addition, in a series of four rat mammary tumors, a rough correlation between prostaglandin synthetase activity and tissue prostaglandin E2 levels was observed. The data suggest a multifactorial explanation for abnormalities of prostaglandin metabolism in human breast cancer.

摘要

在53份人类乳腺癌标本中测量了前列腺素合成酶活性和组织前列腺素E2水平。每组数据呈对数正态分布。单个标本的前列腺素合成酶活性与组织前列腺素E2水平之间存在微弱但具有统计学意义的相关性。此外，在一系列4个大鼠乳腺肿瘤中，观察到前列腺素合成酶活性与组织前列腺素E2水平之间存在大致相关性。数据表明，人类乳腺癌中前列腺素代谢异常存在多因素解释。

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