Laekeman G M, Vergote I B, Keersmaekers G M, Heiremans J, Haensch C F, de Roy G, Uyttenbroeck F L, Herman A G
Br J Cancer. 1986 Sep;54(3):431-7. doi: 10.1038/bjc.1986.194.
6-keto-PGF1 alpha and thromboxane B2 were determined by radioimmunoassay in 37 extracts of breast carcinomata, 8 fibroadenomata, 12 sclerocystic-disease specimens and 51 normal breast tissues. More prostanoids were extracted from carcinomata than from normal specimens, fibroadenomata or sclerocystic-disease tissues (P less than 0.05). The 6-keto-PGF1 alpha/TXB2 ratio was higher in carcinomata than in normal tissues and fibroadenomata (P less than 0.05) but was not significantly different from the ratio in sclerocystic disease. The prostaglandin levels and the 6-keto-PGF1 alpha/TXB2 ratios from carcinomata did not correlate significantly with age, tumour size, differentiation, lymph node status, nuclear-cytoplasmic ratio, host cell reaction, mast cells, necrosis, elastosis, fibrosis or blood vessel density. Lower nuclear density was associated with lower 6-keto-PGF1 alpha/TXB2 ratios (P = 0.01) whereas the latter value was higher when infiltration was lower (P = 0.03). There was a positive correlation between mitotic index and the 6-keto-PGF1 alpha/TXB2 ratio (P = 0.04). Cumulation of variables revealed lower prostanoid ratios in tumours greater than 2 cm without lymph node metastasis then tumours less than 2 cm with lymph node metastasis (P = 0.04). A first follow-up (14 months) showed a higher 6-keto-PGF1 alpha/TXB2 ratio in patients who developed metastasis (P = 0.04). Our study does not confirm the hypothesis that high prostacyclin levels are a good prognostic index in breast cancer.
采用放射免疫分析法测定了37份乳腺癌提取物、8份纤维腺瘤、12份硬化性囊肿病标本及51份正常乳腺组织中的6-酮-前列腺素F1α和血栓素B2。从癌组织中提取的前列腺素比正常标本、纤维腺瘤或硬化性囊肿病组织更多（P<0.05）。癌组织中的6-酮-前列腺素F1α/血栓素B2比值高于正常组织和纤维腺瘤（P<0.05），但与硬化性囊肿病中的比值无显著差异。癌组织中的前列腺素水平及6-酮-前列腺素F1α/血栓素B2比值与年龄、肿瘤大小、分化程度、淋巴结状态、核质比、宿主细胞反应、肥大细胞、坏死、弹性组织变性、纤维化或血管密度均无显著相关性。核密度较低与6-酮-前列腺素F1α/血栓素B2比值较低相关（P = 0.01），而当浸润程度较低时，该比值较高（P = 0.03）。有丝分裂指数与6-酮-前列腺素F1α/血栓素B2比值呈正相关（P = 0.04）。变量累积显示，无淋巴结转移的大于2 cm肿瘤的前列腺素比值低于有淋巴结转移的小于2 cm肿瘤（P = 0.04）。首次随访（14个月）显示，发生转移的患者6-酮-前列腺素F1α/血栓素B2比值较高（P = 0.04）。我们的研究未证实高前列环素水平是乳腺癌良好预后指标的假设。
