Toescu Emil C.
Dept. Physiology, Division Medical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, England.
J Cell Mol Med. 2000 Jul-Sep;4(3):164-175. doi: 10.1111/j.1582-4934.2000.tb00114.x.
Mitochondria play a central role in cell homeostasis. Amongst others, one of the important functions of mitochondria is to integrate its metabolic response with one of the major signaling pathways - the Ca(2+) signaling. Mitochondria are capable to sense the levels of cytosolic Ca(2+) and generate mitochondrial Ca(2+) responses. Specific mechanisms for both Ca(2+) uptake and Ca(2+) release exist in the mitochondrial membranes. In turn, the mitochondrial Ca(2+) signals are able to produce changes in the mitochondrial function and metabolism, which provide the required level of functional integration. This essay reviews briefly the current available information regarding the mitochondrial Ca(2+) transport systems and some of the functional consequences of mitochondrial Ca(2+) uptake.
线粒体在细胞内稳态中发挥着核心作用。其中，线粒体的重要功能之一是将其代谢反应与主要信号通路之一——钙离子信号通路整合起来。线粒体能够感知胞质钙离子水平并产生线粒体钙离子反应。线粒体膜上存在钙离子摄取和释放的特定机制。反过来，线粒体钙离子信号能够引起线粒体功能和代谢的变化，从而实现所需水平的功能整合。本文简要综述了目前有关线粒体钙离子转运系统的现有信息以及线粒体钙离子摄取的一些功能后果。
