Patel M, Wadee A A, Galpin J, Gavalakis C, Fourie A M, Kuschke R H, Philip V
Haematology Unit, Department of Medicine, Chris Hani Baragwanath Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Clin Lab Haematol. 2002 Aug;24(4):215-9. doi: 10.1046/j.1365-2257.2002.00448.x.
While the exact aetiology of myeloma is unknown, genetic factors feature among the potential risk factors. The HLA phenotypes in African blacks with myeloma (the commonest haematopoietic malignancy in this group) have not been characterized. The purpose of this study was to determine the HLA class I and class II phenotypes of patients with multiple myeloma and to compare the findings to an ethnically matched control group of 100 individuals. Analysis of the HLA class I and class II phenotypes in 62 myeloma patients revealed: (i) a corresponding statistically significant association with HLA B18 [odds ratio (OR) 6.3; 95% confidence interval (CI) 1.013-39.727; P < 0.005]; (ii) no statistically significant association with HLA B13, Cw2, Cw6 or the DR and DQ antigens; and (iii) a statistically significant negative (protective) association with HLA Cw7 (OR 0.4; 95% CI 0.21-0.87; P < 0.005). This study suggests that although genetic factors may play a role in the multifactorial aetiology of multiple myeloma, with the exception of HLA B18, there is no specific association between HLA types and multiple myeloma in South African blacks.
虽然骨髓瘤的确切病因尚不清楚，但遗传因素是潜在的风险因素之一。骨髓瘤是非洲黑人中最常见的血液系统恶性肿瘤，其 HLA 表型尚未得到明确描述。本研究的目的是确定多发性骨髓瘤患者的 HLA Ⅰ类和Ⅱ类表型，并将结果与 100 名种族匹配的对照组个体进行比较。对 62 例骨髓瘤患者的 HLA Ⅰ类和Ⅱ类表型分析显示：（i）与 HLA B18 存在统计学上的显著相关性[优势比（OR）6.3；95%置信区间（CI）1.013 - 39.727；P < 0.005]；（ii）与 HLA B13、Cw2、Cw6 或 DR 和 DQ 抗原无统计学上的显著相关性；（iii）与 HLA Cw7 存在统计学上的显著负相关（保护性）（OR 0.4；95%CI 0.21 - 0.87；P < 0.005）。本研究表明，尽管遗传因素可能在多发性骨髓瘤的多因素病因中起作用，但除 HLA B18 外，南非黑人中 HLA 类型与多发性骨髓瘤之间没有特定关联。
