Hornych A, Oravec S, Girault F, Forette B, Horrobin D F
Broussais Hospital, Paris, France.
Bratisl Lek Listy. 2002;103(3):101-7.
Senescence is associated with a decreased activity of enzyme delta-6 desaturase, which converts linoleic acid to gamma-linolenic acid. This enzymatic defect may alter the composition of plasma and membrane lipids, and influences the biosynthesis of renal prostaglandins. Exogenous supplementation of GLA during 3 months increases the plasma level of dihomo-gamma-linolenic acid (p < 0.002), and to a smaller degree, the level in erythrocyte membrane lipids. This treatment was associated with a beneficial reduction of cardiovascular risk factors (arterial hypertension, total cholesterol, apolipoprotein B, HDL-cholesterol, apolipoprotein A-I) and the renal function has become stable reached. Epogam treatment also increased the biosynthesis of renal prostaglandins, especially that of prostaglandin E2, which has a vasodilatory effect on vessel walls and reduces the elevated blood pressure.
Dietary supplementation of essential fatty acids such as gamma-linolenic acid to old subjects has beneficial effect on their health condition. (Tab. 6, Fig. 5, Ref. 37.)
衰老与δ-6去饱和酶活性降低有关，该酶可将亚油酸转化为γ-亚麻酸。这种酶缺陷可能会改变血浆和膜脂质的组成，并影响肾前列腺素的生物合成。在3个月期间外源性补充γ-亚麻酸可提高二高-γ-亚麻酸的血浆水平（p<0.002），并在较小程度上提高红细胞膜脂质水平。这种治疗与心血管危险因素（动脉高血压、总胆固醇、载脂蛋白B、高密度脂蛋白胆固醇、载脂蛋白A-I）的有益降低相关，并且肾功能已达到稳定。Epogam治疗还增加了肾前列腺素的生物合成，尤其是具有血管舒张作用并降低血压升高的前列腺素E2的生物合成。
向老年受试者膳食补充必需脂肪酸如γ-亚麻酸对其健康状况有有益影响。（表6，图5，参考文献37）
