Eary Janet F, O'Sullivan Finbarr, Powitan Yudi, Chandhury Kingshuk Roy, Vernon Cheryl, Bruckner James D, Conrad Ernest U
University of Washington Medical Center, Division of Nuclear Medicine, Box 356113, Seattle WA 98195-6113, Washington, USA.
Eur J Nucl Med Mol Imaging. 2002 Sep;29(9):1149-54. doi: 10.1007/s00259-002-0859-5. Epub 2002 Jun 19.
In a retrospective analysis of patients with sarcoma who underwent fluorodeoxyglucose positron emission tomography (FDG PET) imaging, tumor maximum FDG uptake was analyzed for ability to predict patient survival and disease-free interval. Two hundred and nine patients with sarcoma were imaged prior to treatment with neoadjuvant chemotherapy or resection. Tumor FDG uptake expressed as maximum standard uptake value (SUV(max)) was compared with disease-free and overall survival. A multivariate Cox regression analysis was applied to examine the role of SUV(max) in predicting time to death or disease progression, after adjusting for standard clinical prognostic factors. The multivariate analyses showed that the SUV(max) information is a statistically significant independent predictor of patient survival. Tumors with larger SUV(max) have a significantly poorer prognosis. This retrospective analysis indicates that the sarcoma tumor SUV(max) value determined by PET is an independent predictor of survival and disease progression.
在一项对接受氟脱氧葡萄糖正电子发射断层扫描（FDG PET）成像的肉瘤患者的回顾性分析中，分析了肿瘤最大FDG摄取量预测患者生存率和无病间期的能力。209例肉瘤患者在接受新辅助化疗或手术切除治疗前进行了成像。将以最大标准摄取值（SUV(max)）表示的肿瘤FDG摄取量与无病生存率和总生存率进行比较。在调整标准临床预后因素后，应用多变量Cox回归分析来检验SUV(max)在预测死亡时间或疾病进展中的作用。多变量分析表明，SUV(max)信息是患者生存的统计学显著独立预测因子。SUV(max)较大的肿瘤预后明显较差。这项回顾性分析表明，PET测定的肉瘤肿瘤SUV(max)值是生存和疾病进展的独立预测因子。
