Grizelj V, Drobnjak P, Simunić V
Jugosl Ginekol Opstet. 1979 Sep-Dec;19(5-6):249-52.
Six patients with primary amenorrhea and hyperprolactinemia are presented. The patients had normal secondary characteristics and normal body proportions. In four patients a tumour of the hypophysis was diagnosed radiologically, while in two patients the cause of hyperprolactinemia remained unknown. The gonadotropin concentration in the serum was normal. Reaction to Gn-RH was the same as that in women with the normal cycle in the follicular phase. In all the patients with function of the thyroid was normal. Primary amenorrhea was found in 14.6% of women with a disturbed cycle and hyperprolactinemia. In all the patients the administration of bromocryptin normalized prolactin concentrations, induced ovulation, and four patients became pregnant.
本文报告了6例原发性闭经伴高催乳素血症的患者。这些患者的第二性征及身体比例均正常。4例患者经放射学检查诊断为垂体肿瘤，2例患者高催乳素血症的病因不明。患者血清促性腺激素浓度正常。对Gn-RH的反应与处于卵泡期的正常月经周期女性相同。所有患者的甲状腺功能均正常。在月经周期紊乱伴高催乳素血症的女性中，原发性闭经的发生率为14.6%。所有患者服用溴隐亭后催乳素浓度恢复正常，诱导排卵，4例患者怀孕。
