Smiljanić N, Ciglar S, Podobnik M
Jugosl Ginekol Opstet. 1981 May-Aug;21(3-4):65-9.
In six patients estrogens and gonadotropins were low and the prolactin concentration was increased (36-128 micrograms/l). Amenorrhea in all patients lasted 8-60 months, while galactorrhea was observed in five patients. By the X-ray of the sella turcica and neurologic and ophthalmologic examinations no signs of an intrasellar expansive process were revealed. The progesterone test was negative in four patients and the clomiphene test in all six patients. The LH-RH test (100 micrograms i. m.) showed the increased LH and FSH concentrations in all six patients. They all became pregnant in the course of the bromocryptine treatment (5-7.5 mg daily). Pregnanediol and prolactin concentrations were recorded every 14 days in the first 16 weeks of pregnancy, both in six patients and in eleven controls with spontaneous pregnancy. The pregnanediol concentrations proved somewhat higher in the control group than in patients having become pregnant under the bromocryptine therapy, but the differences are not statistically significant. However, the prolactin concentrations were significantly lower in controls than in pregnant women with the hyperprolactinemic anovulatory syndrome (p less than 0.01) in the sixth to the twelfth week of pregnancy.
6例患者雌激素和促性腺激素水平低，催乳素浓度升高（36 - 128微克/升）。所有患者闭经持续8 - 60个月，5例患者出现溢乳。经蝶鞍X线检查及神经和眼科检查，未发现鞍内占位性病变迹象。4例患者孕激素试验阴性，所有6例患者克罗米芬试验阴性。促黄体生成素释放激素试验（肌肉注射100微克）显示，所有6例患者促黄体生成素和促卵泡激素浓度升高。她们在溴隐亭治疗（每日5 - 7.5毫克）过程中均怀孕。在怀孕的前16周，每14天记录6例患者及11例自然受孕对照者的孕二醇和催乳素浓度。结果显示，对照组孕二醇浓度略高于溴隐亭治疗后怀孕的患者，但差异无统计学意义。然而，在怀孕第6至12周，对照组催乳素浓度显著低于高催乳素血症无排卵综合征孕妇（p < 0.01）。
