Lewis Blair S, Swain Paul
Gastrointest Endosc. 2002 Sep;56(3):349-53. doi: 10.1016/s0016-5107(02)70037-0.
A video capsule has been developed to acquire photographic images of the small intestine during normal peristaltic motion.
Patients between 21 and 80 years of age referred for enteroscopy because of obscure GI bleeding were offered entry into a trial in which they would undergo both capsule endoscopy and subsequent push enteroscopy. Results of capsule examinations were compared with push enteroscopy findings. Capsule endoscopy was performed with the Given M2A video capsule system.
Twenty-one patients (12 women, 9 men, average age 61 years) were enrolled, all of whom completed the study. A bleeding site was found in 11 of 20 patients during capsule endoscopy. No additional intestinal diagnoses were made by enteroscopy. The yield of push enteroscopy in the evaluation of obscure bleeding was 30% (6/20), the yield of capsule endoscopy 55% (11/20). This difference did not reach statistical significance (p = 0.0625). Capsule endoscopy found a distal source of bleeding in 5 of 14 patients who had normal push enteroscopic examinations. Patients preferred capsule endoscopy to enteroscopy.
This pilot study demonstrates that capsule endoscopy provides excellent visualization of the small intestine, is well tolerated by patients, and is safe. Capsule endoscopy identified small intestinal bleeding sites beyond the range of push enteroscopy.
已研发出一种视频胶囊，用于在小肠正常蠕动过程中获取小肠的照片图像。
因不明原因胃肠道出血而被转诊进行小肠镜检查的21至80岁患者被纳入一项试验，在该试验中他们将接受胶囊内镜检查及随后的推进式小肠镜检查。将胶囊检查结果与推进式小肠镜检查结果进行比较。胶囊内镜检查使用Given M2A视频胶囊系统进行。
招募了21名患者（12名女性，9名男性，平均年龄61岁），所有患者均完成了研究。在20名患者中的11名患者的胶囊内镜检查过程中发现了出血部位。小肠镜检查未做出其他肠道诊断。推进式小肠镜检查在评估不明原因出血中的检出率为30%（6/20），胶囊内镜检查的检出率为55%（11/20）。这种差异未达到统计学显著性（p = 0.0625）。在14名推进式小肠镜检查结果正常的患者中，胶囊内镜检查发现了5名患者的远端出血源。患者更喜欢胶囊内镜检查而非小肠镜检查。
这项初步研究表明，胶囊内镜检查能很好地观察小肠，患者耐受性良好且安全。胶囊内镜检查可识别推进式小肠镜检查范围之外的小肠出血部位。
